SLCO1B3 - Solute carrier organic anion transporter family member 1B3 - human protein (Function)
 
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Protein
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SLCO1B3 »  Solute carrier organic anion transporter family member 1B3
 
Protein also known as:  Liver-specific organic anion transporter 2 (LST-2).
Gene name:  SLCO1B3
Entry whose protein(s) existence is based on evidence at protein level
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1 75 1
GENE REF ISO

Function

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Overview 
Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the organo anion transporter (oat) family  2.A.60.1.12  
GO molecular function 
Organic anion transmembrane transporter activitydefinition[GO:0008514]  
1
  • TASPINC
GO biological process 
Organic anion transportdefinition[GO:0015711]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Bile secretion  hsa04976+28234  
According to Reactome, this protein belongs to the following pathways:
Metabolism  REACT_111217  
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: SLCO1B3
GenomeRNAi: 28234
PRO: PR:Q9NPD5
Chemistry
GuidetoPHARMACOLOGY: 1221