SLCO1B3 - Solute carrier organic anion transporter family member 1B3 - human protein (Medical)
 
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SLCO1B3 »  Solute carrier organic anion transporter family member 1B3
 
Protein also known as:  Liver-specific organic anion transporter 2 (LST-2).
Gene name:  SLCO1B3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Displayed isoform: Iso 1     

 
 

Medical

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Disease 
Hyperbilirubinemia, Rotor type (HBLRR) [MIM:237450]: An autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal. The disease is caused by mutations affecting the gene represented in this entry.  
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  • UniProtKB
According to Orphanet, this protein is involved in the following disease:
Rotor syndrome  3111  
Pharmaceutical 
According to DrugBank, this protein binds/interacts with the following drugs:
Atorvastatin  DB01076  
Cabazitaxel  DB06772  
Caspofungin  DB00520  
Conjugated Estrogens  DB00286  
Dabrafenib  DB08912  
Digoxin  DB00390  
Docetaxel  DB01248  
Estradiol  DB00783  
Fexofenadine  DB00950  
Fluvastatin  DB01095  
Gadoxetate  DB08884  
Levothyroxine  DB00451  
Liothyronine  DB00279  
Liotrix  DB01583  
Methotrexate  DB00563  
Mycophenolate mofetil  DB00688  
Olmesartan  DB00275  
Ouabain  DB01092  
Paclitaxel  DB01229  
Pioglitazone  DB01132  
Pitavastatin  DB08860  
Pravastatin  DB00175  
Rifampicin  DB01045  
Rilpivirine  DB08864  
Rosuvastatin  DB01098  
Valsartan  DB00177  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Organism-specific databases
CTD: 28234
GeneReviews: SLCO1B3
MIM: 237450
PharmGKB: PA35844
Polymorphism databases
DMDM: 27734563
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.