IL23A - Interleukin-23 subunit alpha - human protein (Function)
 
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IL23A »  Interleukin-23 subunit alpha  (IL-23-A)
 
Protein also known as:  Interleukin-23 subunit p19 (IL-23p19).
Gene name:  IL23A
Family name: IL-6
Entry whose protein(s) existence is based on evidence at protein level
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1 157 1
GENE REF ISO

Function

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Overview 
Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.  
3
  • CuratedUniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
  • IEAUniProtKB KW
Contributes to interleukin-23 receptor bindingdefinition[GO:0045519]  
1
  • IDABHF-UCL
GO biological process 
Defense response to Gram-negative bacteriumdefinition[GO:0050829]  
2
  • IDABHF-UCL
Defense response to virusdefinition[GO:0051607]  
  • IEAUniProtKB KW
Inflammatory responsedefinition[GO:0006954]  
  • IEAUniProtKB KW
Innate immune responsedefinition[GO:0045087]  
  • IEAUniProtKB KW
Negative regulation of interleukin-10 productiondefinition[GO:0032693]  
1
  • IMPBHF-UCL
Positive regulation of activated T cell proliferationdefinition[GO:0042104]  
1
  • IDABHF-UCL
Positive regulation of activation of JAK2 kinase activitydefinition[GO:0010535]  
1
  • IDABHF-UCL
Positive regulation of defense response to virus by hostdefinition[GO:0002230]  
1
  • IDABHF-UCL
  • ISSOrtholog Curator
Positive regulation of granulocyte macrophage colony-stimulating factor productiondefinition[GO:0032725]  
1
  • IDABHF-UCL
Positive regulation of inflammatory responsedefinition[GO:0050729]  
1
  • ICBHF-UCL
Positive regulation of interferon-gamma productiondefinition[GO:0032729]  
4
  • TASBHF-UCL
Positive regulation of interleukin-10 productiondefinition[GO:0032733]  
2
  • TASBHF-UCL
Positive regulation of interleukin-12 productiondefinition[GO:0032735]  
1
  • IDABHF-UCL
Positive regulation of interleukin-17 productiondefinition[GO:0032740]  
3
  • IDABHF-UCL
Positive regulation of memory T cell differentiationdefinition[GO:0043382]  
  • ISSOrtholog Curator
Positive regulation of natural killer cell activationdefinition[GO:0032816]  
1
  • ICBHF-UCL
Positive regulation of natural killer cell proliferationdefinition[GO:0032819]  
1
  • IDABHF-UCL
Positive regulation of neutrophil chemotaxisdefinition[GO:0090023] silver  
  • IEAOrtholog Compara
Positive regulation of NF-kappaB import into nucleusdefinition[GO:0042346]  
1
  • TASBHF-UCL
Positive regulation of NK T cell activationdefinition[GO:0051135]  
2
  • IDABHF-UCL
Positive regulation of NK T cell proliferationdefinition[GO:0051142]  
1
  • IDABHF-UCL
Positive regulation of osteoclast differentiationdefinition[GO:0045672]  
1
  • IDABHF-UCL
Positive regulation of T cell mediated cytotoxicitydefinition[GO:0001916]  
  • ISSOrtholog Curator
Positive regulation of T cell proliferationdefinition[GO:0042102]  
1
  • IDABHF-UCL
Positive regulation of T-helper 1 type immune responsedefinition[GO:0002827]  
3
  • NASBHF-UCL
  • ISSOrtholog Curator
Positive regulation of T-helper 17 cell lineage commitmentdefinition[GO:2000330]  
  • ISSOrtholog Curator
Positive regulation of T-helper 17 type immune responsedefinition[GO:2000318]  
  • ISSOrtholog Curator
Positive regulation of tissue remodelingdefinition[GO:0034105]  
1
  • ICBHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Positive regulation of tumor necrosis factor productiondefinition[GO:0032760]  
1
  • IMPBHF-UCL
Positive regulation of tyrosine phosphorylation of Stat3 proteindefinition[GO:0042517]  
2
  • IDABHF-UCL
Positive regulation of tyrosine phosphorylation of Stat4 proteindefinition[GO:0042520]  
3
  • IDABHF-UCL
Positive regulation of tyrosine phosphorylation of Stat5 proteindefinition[GO:0042523]  
1
  • IDABHF-UCL
Regulation of tyrosine phosphorylation of Stat1 proteindefinition[GO:0042510]  
1
  • IDABHF-UCL
T cell proliferationdefinition[GO:0042098] silver  
  • IEAOrtholog Compara
Tissue remodelingdefinition[GO:0048771]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+51561  
Jak-STAT signaling pathway  hsa04630+51561  
Pertussis  hsa05133+51561  
Rheumatoid arthritis  hsa05323+51561  
Tuberculosis  hsa05152+51561  
 

Keywords

Biological process 
Antiviral defense  definition   [KW-0051]
Immunity  definition   [KW-0391]
Inflammatory response  definition   [KW-0395]
Innate immunity  definition   [KW-0399]
Tissue remodeling  definition   [KW-0797]
Molecular function 
Cytokine  definition   [KW-0202]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Interleukin_23
GenomeRNAi: 51561
PRO: PR:Q9NPF7