FZD3 - Frizzled-3 - human protein (Function)
 
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FZD3 »  Frizzled-3  (Fz-3)
 
Gene name:  FZD3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including: the anterior commissure, the corpus callosum, the thalamocortical, corticothalamic and nigrostriatal tracts, the corticospinal tract, the fasciculus retroflexus, the mammillothalamic tract, the medial lemniscus, and ascending fiber tracts from the spinal cord to the brain. In the peripheral nervous system, controls axon growth in distinct populations of cranial and spinal motor neurons, including the facial branchimotor nerve, the hypoglossal nerve, the phrenic nerve, and motor nerves innervating dorsal limbs. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner (By similarity).  
2
  • UniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • RefGenome
PDZ domain bindingdefinition[GO:0030165]  
2
  • UniProtKB
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
Wnt-activated receptor activitydefinition[GO:0042813]  
2
  • BHF-UCL
  • RefGenome
Wnt-protein bindingdefinition[GO:0017147]  
1
  • UniProtKB
GO biological process 
Canonical Wnt signaling pathwaydefinition[GO:0060070]  
1
  • UniProtKB
Cell proliferation in midbraindefinition[GO:0033278] silver  
1
  • Ortholog Compara
Commissural neuron axon guidancedefinition[GO:0071679] silver  
1
  • Ortholog Compara
Establishment of planar polaritydefinition[GO:0001736] silver  
1
  • Ortholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • UniProtKB KW
Hair follicle developmentdefinition[GO:0001942] silver  
1
  • Ortholog Compara
Inner ear morphogenesisdefinition[GO:0042472] silver  
1
  • Ortholog Compara
Negative regulation of execution phase of apoptosisdefinition[GO:1900118]  
1
  • Ortholog Curator
Negative regulation of mitotic cell cycle, embryonicdefinition[GO:0045976]  
1
  • Ortholog Curator
Neural tube closuredefinition[GO:0001843] silver  
1
  • Ortholog Compara
Neuron differentiationdefinition[GO:0030182]  
1
  • Ortholog Curator
Neuron migrationdefinition[GO:0001764] silver  
1
  • Ortholog Compara
Non-canonical Wnt signaling pathwaydefinition[GO:0035567]  
1
  • RefGenome
Positive regulation of neuroblast proliferationdefinition[GO:0002052]  
1
  • Ortholog Curator
Post-anal tail morphogenesisdefinition[GO:0036342] silver  
1
  • Ortholog Compara
Sympathetic ganglion developmentdefinition[GO:0061549]  
1
  • Ortholog Curator
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Basal cell carcinoma  hsa05217+7976  
HTLV-I infection  hsa05166+7976  
Melanogenesis  hsa04916+7976  
Pathways in cancer  hsa05200+7976  
Wnt signaling pathway  hsa04310+7976  
According to Reactome, this protein belongs to the following pathways:
Asymmetric localization of PCP proteins  REACT_264478  
Ca2+ pathway  REACT_263982  
Class B/2 (Secretin family receptors)  REACT_18372  
PCP/CE pathway  REACT_264199  
 

Keywords

Biological process 
Neurogenesis  definition   [KW-0524]
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Developmental protein  definition   [KW-0217]
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FZD3
GenomeRNAi: 7976
PRO: PR:Q9NPG1