FZD3 - Frizzled-3 - human protein (Function)
 
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FZD3 »  Frizzled-3  (Fz-3)
 
Gene name:  FZD3
Entry whose protein(s) existence is based on evidence at protein level
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1 27 1
GENE REF ISO

Function

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Overview 
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.  
  • CuratedUniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
  • IEAUniProtKB KW
PDZ domain bindingdefinition[GO:0030165]  
2
  • IPIUniProtKB
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Wnt-activated receptor activitydefinition[GO:0042813]  
1
  • ICBHF-UCL
  • IBARefGenome
Wnt-protein bindingdefinition[GO:0017147]  
1
  • IPIUniProtKB
GO biological process 
Canonical Wnt signaling pathwaydefinition[GO:0060070]  
1
  • IDAUniProtKB
Cell proliferation in midbraindefinition[GO:0033278] silver  
  • IBARefGenome
Commissural neuron axon guidancedefinition[GO:0071679] silver  
  • IBARefGenome
Establishment of planar polaritydefinition[GO:0001736] silver  
  • IBARefGenome
Facial nucleus developmentdefinition[GO:0021754] silver  
  • IBARefGenome
G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerdefinition[GO:0007199] silver  
  • IBARefGenome
Gonad developmentdefinition[GO:0008406] silver  
  • IBARefGenome
Hair follicle developmentdefinition[GO:0001942] silver  
  • IEAOrtholog Compara
Inner ear morphogenesisdefinition[GO:0042472] silver  
  • IBARefGenome
Neural tube closuredefinition[GO:0001843] silver  
  • IBARefGenome
Neuron differentiationdefinition[GO:0030182]  
  • ISSOrtholog Curator
Neuron migrationdefinition[GO:0001764] silver  
  • IEAOrtholog Compara
Post-anal tail morphogenesisdefinition[GO:0036342] silver  
  • IEAOrtholog Compara
Vasculature developmentdefinition[GO:0001944] silver  
  • IBARefGenome
Pathways 
According to KEGG, this protein belongs to the following pathways:
Basal cell carcinoma  hsa05217+7976  
HTLV-I infection  hsa05166+7976  
Melanogenesis  hsa04916+7976  
Pathways in cancer  hsa05200+7976  
Wnt signaling pathway  hsa04310+7976  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Developmental protein  definition   [KW-0217]
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FZD3
GenomeRNAi: 7976
PRO: PR:Q9NPG1