ISYNA1 - Inositol-3-phosphate synthase 1 - human protein (Function)
 
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ISYNA1 »  Inositol-3-phosphate synthase 1   [ EC 5.5.1.4 ]  (IPS 1)
 
Protein also known as:  Myo-inositol 1-phosphate synthase A1.
Gene name:  ISYNA1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 22 3
GENE REF ISO

Function

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Overview 
Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds.  
1
  • CuratedUniProtKB
GO biological process 
Inositol biosynthetic processdefinition[GO:0006021]  
  • IEAUniPathway
Phospholipid biosynthetic processdefinition[GO:0008654]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.5.1.4: D-glucose 6-phosphate 1D-myo-inositol 3-phosphate.  
1
  • CuratedUniProtKB
It requires the following cofactor
NAD.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by mood-stabilizing drugs such as valproate (VPA) and lithium.  
2
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Inositol phosphate metabolism  hsa00562+51477  
Metabolic pathways  hsa01100+51477  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Biophysicochemical properties

Kinetic parameters
KM 8 uM for NAD
KM 0.57 mM for 6-phosphate
Dependence
pH Optimum pH is 8.0.

Keywords

Biological process 
Inositol biosynthesis  definition   [KW-0398]
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Phospholipid biosynthesis  definition   [KW-0594]
Phospholipid metabolism  definition   [KW-1208]
Molecular function 
Isomerase  definition   [KW-0413]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 51477
PRO: PR:Q9NPH2