NOX4 - NADPH oxidase 4 - human protein (Function)
 
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NOX4 »  NADPH oxidase 4   [ EC 1.6.3.- ]
 
Protein also known as:  Kidney superoxide-producing NADPH oxidase.
Gene name:  NOX4
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 141 9
GENE REF ISO

Function

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Overview 
Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation.  
11
  • CuratedUniProtKB
Isoforms  Iso 5 and Iso 6   Display reduced activity.  
11
  • CuratedUniProtKB
Isoform  Iso 3   Is not functional.  
11
  • CuratedUniProtKB
Isoform  Iso 4   Displays an increased activity.  
11
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the phagocyte (gp91(phox)) nadph oxidase family  5.B.1.1.2  
GO molecular function 
Electron carrier activitydefinition[GO:0009055]  
1
  • TASUniProtKB
Flavin adenine dinucleotide bindingdefinition[GO:0050660]  
1
  • TASUniProtKB
Heme bindingdefinition[GO:0020037]  
1
  • TASUniProtKB
Modified amino acid bindingdefinition[GO:0072341]  
1
  • IDAUniProtKB
NAD(P)H oxidase activitydefinition[GO:0016174]  
1
  • TASUniProtKB
Nucleotide bindingdefinition[GO:0000166]  
1
  • TASUniProtKB
Oxygen sensor activitydefinition[GO:0019826]  
1
  • TASUniProtKB
Superoxide-generating NADPH oxidase activitydefinition[GO:0016175] silver  
  • IEAOrtholog Compara
GO biological process 
Bone resorptiondefinition[GO:0045453] silver  
  • IEAOrtholog Compara
Cardiocyte differentiationdefinition[GO:0035051] silver  
  • IEAOrtholog Compara
Cell agingdefinition[GO:0007569]  
1
  • ISSUniProtKB
Cell morphogenesisdefinition[GO:0000902]  
1
  • ISSUniProtKB
Cellular response to cAMPdefinition[GO:0071320] silver  
  • IEAOrtholog Compara
Cellular response to gamma radiationdefinition[GO:0071480] silver  
  • IEAOrtholog Compara
Cellular response to glucose stimulusdefinition[GO:0071333] silver  
  • IEAOrtholog Compara
Cellular response to transforming growth factor beta stimulusdefinition[GO:0071560] silver  
  • IEAOrtholog Compara
Homocysteine metabolic processdefinition[GO:0050667]  
1
  • IDAUniProtKB
Inflammatory responsedefinition[GO:0006954]  
1
  • TASUniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • ISSUniProtKB
Oxidation-reduction processdefinition[GO:0055114]  
1
  • IDAUniProtKB
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
  • IEAOrtholog Compara
Positive regulation of DNA biosynthetic processdefinition[GO:2000573] silver  
  • IEAOrtholog Compara
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374] silver  
  • IEAOrtholog Compara
Positive regulation of MAP kinase activitydefinition[GO:0043406] silver  
  • IEAOrtholog Compara
Positive regulation of protein kinase B signalingdefinition[GO:0051897] silver  
  • IEAOrtholog Compara
Positive regulation of reactive oxygen species metabolic processdefinition[GO:2000379] silver  
  • IEAOrtholog Compara
Positive regulation of smooth muscle cell migrationdefinition[GO:0014911] silver  
  • IEAOrtholog Compara
Positive regulation of stress fiber assemblydefinition[GO:0051496] silver  
  • IEAOrtholog Compara
Reactive oxygen species metabolic processdefinition[GO:0072593]  
1
  • IDAUniProtKB
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Superoxide anion generationdefinition[GO:0042554]  
1
  • ISSUniProtKB
Enzymatic activity 
It is regulated in the following manner
Inhibited by plumbagin (By similarity). Activated by phorbol 12-myristate 13-acetate (PMA). Activated by insulin. Inhibited by diphenylene iodonium.  
4
  • CuratedUniProtKB
 
More information is available from:
  • PeroxiBase: 5967 [ HsNOx04 ]
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: NOX4
GenomeRNAi: 50507
PRO: PR:Q9NPH5