KCNJ16 - Inward rectifier potassium channel 16 - human protein (Function)
 
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Protein
Gene
References

 
KCNJ16 »  Inward rectifier potassium channel 16
 
Protein also known as:  Potassium channel, inwardly rectifying subfamily J member 16.
Gene name:  KCNJ16
Entry whose protein(s) existence is based on evidence at transcript level
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1 19 1
GENE REF ISO

Function

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Overview 
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
inward rectifier k(+) channel (irk-c) family  1.A.2.1.11  
GO molecular function 
Inward rectifier potassium channel activitydefinition[GO:0005242]  
1
  • NASUniProtKB
GO biological process 
Potassium ion transmembrane transportdefinition[GO:0071805]  
1
  • NASGOC
  • IEAInterPro 2 GO
Potassium ion transportdefinition[GO:0006813]  
1
  • NASUniProtKB
Regulation of ion transmembrane transportdefinition[GO:0034765]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Gastric acid secretion  hsa04971+3773  
According to Reactome, this protein belongs to the following pathways:
Activation of G protein gated Potassium channels  REACT_75831  
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits  REACT_25004  
Potassium transport channels  REACT_75815  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: KCNJ16
GenomeRNAi: 3773
PRO: PR:Q9NPI9