ACOT13 - Acyl-coenzyme A thioesterase 13 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
ACOT13 »  Acyl-coenzyme A thioesterase 13   [ EC 3.1.2.- ]  (Acyl-CoA thioesterase 13)
 
Protein also known as:  Thioesterase superfamily member 2. Cleaved into:  Acyl-coenzyme A thioesterase 13, N-terminally processed.
Gene name:  ACOT13
Family name: UPF0152
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 17 2
GENE REF ISO

Function

 show evidences
Overview 
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro).  
2
  • CuratedUniProtKB
GO molecular function 
Acyl-CoA hydrolase activitydefinition[GO:0047617]  
2
  • IDAUniProtKB
GO biological process 
Metabolic processdefinition[GO:0008152]  
2
  • IDAGOC
Protein homotetramerizationdefinition[GO:0051289]  
2
  • IPIUniProtKB
 

Biophysicochemical properties

Kinetic parameters
KM 4.9 uM for n-decanoyl-CoA
KM 5 uM for myristoyl-CoA
KM 9 uM for oleoyl-CoA
KM 26 uM for n-octanoyl-CoA
KM 40 uM for 3-hydroxyphenylacetyl-CoA
KM 9 uM for palmitoyl-CoA
KM 10 uM for 3,4-dihydroxyphenylacetyl-CoA

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q9NPJ3
Other
GenomeRNAi: 55856
PRO: PR:Q9NPJ3