SPINK5 - Serine protease inhibitor Kazal-type 5 - human protein (Function)
 
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SPINK5 »  Serine protease inhibitor Kazal-type 5
 
Protein also known as:  Lympho-epithelial Kazal-type-related inhibitor (LEKTI). Cleaved into:  Hemofiltrate peptide HF6478; Hemofiltrate peptide HF7665.
Gene name:  SPINK5
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin.  
3
  • CuratedUniProtKB
GO molecular function 
Serine-type endopeptidase inhibitor activitydefinition[GO:0004867]  
2
  • IDAUniProtKB
GO biological process 
Anagendefinition[GO:0042640]  
1
  • TASUniProtKB
Epidermal cell differentiationdefinition[GO:0009913]  
1
  • IDAUniProtKB
Epithelial cell differentiationdefinition[GO:0030855]  
1
  • TASUniProtKB
Extracellular matrix organizationdefinition[GO:0030198]  
1
  • TASUniProtKB
Hair cell differentiationdefinition[GO:0035315]  
1
  • TASUniProtKB
Negative regulation of angiogenesisdefinition[GO:0016525]  
1
  • TASUniProtKB
Negative regulation of endopeptidase activitydefinition[GO:0010951]  
2
  • IDAGOC
Negative regulation of immune responsedefinition[GO:0050777]  
1
  • TASUniProtKB
Negative regulation of proteolysisdefinition[GO:0045861] silver  
  • IEAOrtholog Compara
Regulation of cell adhesiondefinition[GO:0030155] silver  
  • IEAOrtholog Compara
Regulation of endopeptidase activitydefinition[GO:0052548]  
2
  • IDAGOC
Regulation of T cell differentiationdefinition[GO:0045580]  
1
  • TASUniProtKB
Enzymatic activity 
 
More information is available from:
 

Keywords

Molecular function 
Protease inhibitor  definition   [KW-0646]
Serine protease inhibitor  definition   [KW-0722]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q9NQ38
Other
GeneWiki: LEKTI
GenomeRNAi: 11005
PRO: PR:Q9NQ38