PLCB1 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 - human protein (Function)
 
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PLCB1 »  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1   [ EC 3.1.4.11 ]
 
Protein also known as:  Phosphoinositide phospholipase C-beta-1.
Gene name:  PLCB1
Entry whose protein(s) existence is based on evidence at protein level
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1 74 2
GENE REF ISO

Function

 show evidences
Overview 
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.  
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Calmodulin bindingdefinition[GO:0005516]  
1
  • IPIBHF-UCL
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
GTPase activator activitydefinition[GO:0005096]  
1
  • IDABHF-UCL
Lamin bindingdefinition[GO:0005521] silver  
  • IEAOrtholog Compara
Phosphatidylinositol phospholipase C activitydefinition[GO:0004435]  
1
  • NASUniProtKB
  • ISSOrtholog Curator
Phosphatidylinositol-4,5-bisphosphate bindingdefinition[GO:0005546]  
1
  • IDABHF-UCL
Protein homodimerization activitydefinition[GO:0042803]  
  • ISSOrtholog Curator
Signal transducer activitydefinition[GO:0004871]  
  • IEAUniProtKB KW
GO biological process 
Activation of meiosis involved in egg activationdefinition[GO:0060466]  
  • ISSOrtholog Curator
Cerebral cortex developmentdefinition[GO:0021987]  
  • ISSOrtholog Curator
Fat cell differentiationdefinition[GO:0045444] silver  
  • IEAOrtholog Compara
G-protein coupled acetylcholine receptor signaling pathwaydefinition[GO:0007213]  
  • ISSOrtholog Curator
G2/M transition of mitotic cell cycledefinition[GO:0000086]  
  • ISSOrtholog Curator
Glutamate receptor signaling pathwaydefinition[GO:0007215]  
  • ISSOrtholog Curator
Insulin-like growth factor receptor signaling pathwaydefinition[GO:0048009]  
  • ISSOrtholog Curator
Interleukin-1-mediated signaling pathwaydefinition[GO:0070498]  
1
  • IDABHF-UCL
Interleukin-12-mediated signaling pathwaydefinition[GO:0035722]  
1
  • IDABHF-UCL
Interleukin-15-mediated signaling pathwaydefinition[GO:0035723]  
1
  • IDABHF-UCL
Intracellular signal transductiondefinition[GO:0035556] silver  
  • IEAInterPro 2 GO
Lipid catabolic processdefinition[GO:0016042]  
  • IEAUniProtKB KW
Memorydefinition[GO:0007613]  
  • ISSOrtholog Curator
Negative regulation of monocyte extravasationdefinition[GO:2000438]  
  • ISSOrtholog Curator
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
  • ISSOrtholog Curator
Phosphatidylinositol metabolic processdefinition[GO:0046488]  
  • ISSOrtholog Curator
Positive regulation of acrosome reactiondefinition[GO:2000344]  
  • ISSOrtholog Curator
Positive regulation of catalytic activitydefinition[GO:0043085]  
1
  • IDAGOC
Positive regulation of CD24 biosynthetic processdefinition[GO:2000560]  
  • ISSOrtholog Curator
Positive regulation of developmental growthdefinition[GO:0048639]  
  • ISSOrtholog Curator
Positive regulation of embryonic developmentdefinition[GO:0040019]  
  • ISSOrtholog Curator
Positive regulation of G1/S transition of mitotic cell cycledefinition[GO:1900087]  
  • ISSOrtholog Curator
Positive regulation of GTPase activitydefinition[GO:0043547]  
1
  • IDAGOC
Positive regulation of interleukin-12 productiondefinition[GO:0032735]  
  • ISSOrtholog Curator
Positive regulation of JNK cascadedefinition[GO:0046330]  
1
  • IDABHF-UCL
Positive regulation of myoblast differentiationdefinition[GO:0045663]  
  • ISSOrtholog Curator
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
  • ISSOrtholog Curator
Regulation of catalytic activitydefinition[GO:0050790]  
1
  • IDAGOC
Regulation of fertilizationdefinition[GO:0080154]  
  • ISSOrtholog Curator
Regulation of G-protein coupled receptor protein signaling pathwaydefinition[GO:0008277]  
  • ISSOrtholog Curator
Signal transductiondefinition[GO:0007165]  
1
  • NASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.4.11: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.  
  • CuratedUniProtKB
It requires the following cofactor
Calcium.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
African trypanosomiasis  hsa05143+23236  
Alzheimer's disease  hsa05010+23236  
Amoebiasis  hsa05146+23236  
Calcium signaling pathway  hsa04020+23236  
Chagas disease (American trypanosomiasis)  hsa05142+23236  
Chemokine signaling pathway  hsa04062+23236  
Cholinergic synapse  hsa04725+23236  
Dopaminergic synapse  hsa04728+23236  
Endocrine and other factor-regulated calcium reabsorption  hsa04961+23236  
Gap junction  hsa04540+23236  
Gastric acid secretion  hsa04971+23236  
Glutamatergic synapse  hsa04724+23236  
GnRH signaling pathway  hsa04912+23236  
Huntington's disease  hsa05016+23236  
Inositol phosphate metabolism  hsa00562+23236  
Long-term depression  hsa04730+23236  
Long-term potentiation  hsa04720+23236  
Melanogenesis  hsa04916+23236  
Metabolic pathways  hsa01100+23236  
Pancreatic secretion  hsa04972+23236  
Phosphatidylinositol signaling system  hsa04070+23236  
Salivary secretion  hsa04970+23236  
Vascular smooth muscle contraction  hsa04270+23236  
Wnt signaling pathway  hsa04310+23236  
According to Reactome, this protein belongs to the following pathways:
Metabolism  REACT_111217  
Neuronal System  REACT_13685  
Signal Transduction  REACT_111102  
Note 
The receptor-mediated activation of PLC-beta-1 is mediated by two G-protein alpha subunits, alpha-Q and alpha-11.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Lipid degradation  definition   [KW-0442]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Hydrolase  definition   [KW-0378]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PLCB1
GenomeRNAi: 23236
PRO: PR:Q9NQ66