HEYL - Hairy/enhancer-of-split related with YRPW motif-like protein - human protein (Function)
 
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Gene
References

 
HEYL »  Hairy/enhancer-of-split related with YRPW motif-like protein
 
Protein also known as:  Class B basic helix-loop-helix protein 33 (bHLHb33).
Gene name:  HEYL
Family name: HEY
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 21 1
GENE REF ISO

Function

 show evidences
Overview 
Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity). Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.  
2
  • UniProtKB
GO molecular function 
AF-1 domain bindingdefinition[GO:0050683]  
1
  • UniProtKB
Microsatellite bindingdefinition[GO:0035939]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
5
  • IntAct
  • UniProtKB
Protein binding transcription factor activitydefinition[GO:0000988]  
1
  • UniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • UniProtKB
Protein homodimerization activitydefinition[GO:0042803] silver  
1
  • Ortholog Compara
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077] silver  
1
  • Ortholog Compara
RNA polymerase II core promoter sequence-specific DNA bindingdefinition[GO:0000979] silver  
1
  • Ortholog Compara
RNA polymerase II core promoter sequence-specific DNA binding transcription factor activitydefinition[GO:0000983]  
1
  • Ortholog Curator
RNA polymerase II transcription corepressor activitydefinition[GO:0001106] silver  
1
  • Ortholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • UniProtKB
Transcription corepressor activitydefinition[GO:0003714]  
1
  • UniProtKB
Transcription factor bindingdefinition[GO:0008134]  
1
  • UniProtKB
GO biological process 
Atrioventricular valve morphogenesisdefinition[GO:0003181]  
1
  • Ortholog Curator
Cardiac epithelial to mesenchymal transitiondefinition[GO:0060317]  
1
  • Ortholog Curator
Cardiac ventricle morphogenesisdefinition[GO:0003208]  
1
  • Ortholog Curator
Cellular response to BMP stimulusdefinition[GO:0071773] silver  
1
  • Ortholog Compara
Endocardial cushion morphogenesisdefinition[GO:0003203]  
1
  • Ortholog Curator
Epithelial to mesenchymal transition involved in endocardial cushion formationdefinition[GO:0003198]  
1
  • Ortholog Curator
Glomerulus developmentdefinition[GO:0032835] silver  
1
  • Ortholog Compara
Mesenchymal cell developmentdefinition[GO:0014031]  
1
  • Ortholog Curator
Negative regulation of androgen receptor activitydefinition[GO:2000824]  
1
  • UniProtKB
Negative regulation of androgen receptor signaling pathwaydefinition[GO:0060766]  
1
  • UniProtKB
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
2
  • UniProtKB
Notch signaling pathwaydefinition[GO:0007219]  
1
  • UniProtKB
Outflow tract morphogenesisdefinition[GO:0003151]  
1
  • Ortholog Curator
Positive regulation of neuron differentiationdefinition[GO:0045666]  
1
  • Ortholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • UniProtKB
Proximal tubule developmentdefinition[GO:0072014] silver  
1
  • Ortholog Compara
Pulmonary valve morphogenesisdefinition[GO:0003184]  
1
  • Ortholog Curator
Skeletal muscle cell differentiationdefinition[GO:0035914] silver  
1
  • Ortholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366] silver  
1
  • Ortholog Compara
Ventricular septum morphogenesisdefinition[GO:0060412]  
1
  • Ortholog Curator
Pathways 
According to Reactome, this protein belongs to the following pathways:
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants  REACT_160254  
Constitutive Signaling by NOTCH1 PEST Domain Mutants  REACT_160243  
NOTCH1 Intracellular Domain Regulates Transcription  REACT_118780  
 

Keywords

Biological process 
Notch signaling pathway  definition   [KW-0914]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: HEYL
GenomeRNAi: 26508
PRO: PR:Q9NQ87