ANO2 - Anoctamin-2 - human protein (Function)
 
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Protein
Gene
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ANO2 »  Anoctamin-2
 
Protein also known as:  Transmembrane protein 16B.
Gene name:  ANO2
Family name: Anoctamin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina.  
5
  • UniProtKB
According to TCDB this is a transporter from family:
the calcium-dependent chloride channel (ca-clc) family  1.A.17.1.3  
GO molecular function 
Intracellular calcium activated chloride channel activitydefinition[GO:0005229]  
2
  • UniProtKB
Protein heterodimerization activitydefinition[GO:0046982] silver  
1
  • Ortholog Compara
Protein homodimerization activitydefinition[GO:0042803] silver  
1
  • Ortholog Compara
GO biological process 
Chloride transmembrane transportdefinition[GO:1902476]  
4
  • GOC
  • Ortholog Compara
  • UniProtKB KW
Enzymatic activity 
It is regulated in the following manner
Channel activity is repressed by chloride inhibitors; strongly by niflumic acid (NFA), partially by flufenamic acid (FFA), and only slightly by meclofenamic acid (MFA), 5-Nitro-2-(3-phenylpropylamino)benzoic acid (NPPB), 4-acetamido-4'-isothiocyanato-stilben-2,2'-disulfonate (SITS), and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS).  
1
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Orphan transporters  REACT_268444  
Stimuli-sensing channels  REACT_160189  
Note 
The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.  
1
  • UniProtKB
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Chloride channel  definition   [KW-0869]
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 57101
PRO: PR:Q9NQ90