A1CF - APOBEC1 complementation factor - human protein (Function)
 
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Protein
Gene
References

 
A1CF »  APOBEC1 complementation factor
 
Protein also known as:  APOBEC1-stimulating protein.
Gene name:  A1CF
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

 show evidences
Overview 
Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay.  
4
  • UniProtKB
GO molecular function 
Not  Double-stranded RNA bindingdefinition[GO:0003725]  
1
  • UniProtKB
Nucleotide bindingdefinition[GO:0000166] silver  
1
  • InterPro 2 GO
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
  • UniProtKB
RNA bindingdefinition[GO:0003723]  
1
  • PINC
Single-stranded RNA bindingdefinition[GO:0003727]  
1
  • UniProtKB
GO biological process 
mRNA processingdefinition[GO:0006397]  
1
  • UniProtKB KW
Protein stabilizationdefinition[GO:0050821]  
1
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Formation of the Editosome  REACT_1390  
mRNA Editing: C to U Conversion  REACT_167  
 

Keywords

Biological process 
mRNA processing  definition   [KW-0507]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ACF_(gene)
GenomeRNAi: 29974
PRO: PR:Q9NQ94