TRPV5 - Transient receptor potential cation channel subfamily V member 5 - human protein (Function)
 
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TRPV5 »  Transient receptor potential cation channel subfamily V member 5  (TrpV5)
 
Protein also known as:  Epithelial calcium channel 1 (ECaC).
Gene name:  TRPV5
Entry whose protein(s) existence is based on evidence at protein level
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1 66 1
GENE REF ISO

Function

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Overview 
Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the transient receptor potential ca(2+) channel (trp-cc) family  1.A.4.2.10  
GO molecular function 
Calcium channel activitydefinition[GO:0005262]  
  • ISSOrtholog Curator
Calmodulin bindingdefinition[GO:0005516]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Calcium ion transportdefinition[GO:0006816]  
1
  • TASUniProtKB
  • ISSOrtholog Curator
Calcium ion transport into cytosoldefinition[GO:0060402] silver  
  • IEAOrtholog Compara
Protein tetramerizationdefinition[GO:0051262]  
  • ISSOrtholog Curator
Enzymatic activity 
It is regulated in the following manner
Activated by WNK3.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Endocrine and other factor-regulated calcium reabsorption  hsa04961+56302  
According to Reactome, this protein belongs to the following pathway:
TRP channels  REACT_169333  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: TRPV5
GenomeRNAi: 56302
PRO: PR:Q9NQA5
Chemistry
GuidetoPHARMACOLOGY: 511