TCF7L2 - Transcription factor 7-like 2 - human protein (Function)
 
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TCF7L2 »  Transcription factor 7-like 2
 
Gene name:  TCF7L2
Family name: TCF/LEF
Entry whose protein(s) existence is based on evidence at protein level
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1 299 17
GENE REF ISO

Function

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Overview 
Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.  
5
  • CuratedUniProtKB
GO molecular function 
Armadillo repeat domain bindingdefinition[GO:0070016]  
1
  • IPIBHF-UCL
Beta-catenin bindingdefinition[GO:0008013]  
3
  • IPIBHF-UCL
Chromatin bindingdefinition[GO:0003682] silver  
  • IBARefGenome
Gamma-catenin bindingdefinition[GO:0045295]  
1
  • IPIBHF-UCL
Nuclear hormone receptor bindingdefinition[GO:0035257]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
16
  • IPIUniProtKB
  • IPIIntAct
  • IPIBHF-UCL
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIUniProtKB
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • IDABHF-UCL
RNA polymerase II repressing transcription factor bindingdefinition[GO:0001103]  
1
  • IPIBHF-UCL
Sequence-specific DNA bindingdefinition[GO:0043565]  
2
  • IMPUniProtKB
  • IDABHF-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • IDABHF-UCL
Transcription factor bindingdefinition[GO:0008134]  
1
  • IPIBHF-UCL
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • IDAUniProtKB
GO biological process 
Blood vessel developmentdefinition[GO:0001568]  
1
  • IMPBHF-UCL
Bone mineralizationdefinition[GO:0030282] silver  
  • IEAOrtholog Compara
Brain developmentdefinition[GO:0007420] silver  
  • IBARefGenome
Canonical Wnt signaling pathwaydefinition[GO:0060070]  
1
  • ICBHF-UCL
Canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transitiondefinition[GO:0044334]  
1
  • IMPBHF-UCL
Catenin import into nucleusdefinition[GO:0035411] silver  
  • IEAOrtholog Compara
Cell cycle arrestdefinition[GO:0007050]  
1
  • IMPBHF-UCL
Cell proliferationdefinition[GO:0008283]  
1
  • IMPBHF-UCL
Embryonic digestive tract morphogenesisdefinition[GO:0048557] silver  
  • IEAOrtholog Compara
Embryonic genitalia morphogenesisdefinition[GO:0030538] silver  
  • IEAOrtholog Compara
Embryonic hindgut morphogenesisdefinition[GO:0048619] silver  
  • IEAOrtholog Compara
Face morphogenesisdefinition[GO:0060325] silver  
  • IEAOrtholog Compara
Fat cell differentiationdefinition[GO:0045444]  
1
  • IDABHF-UCL
Generation of neuronsdefinition[GO:0048699] silver  
  • IBARefGenome
Glucose homeostasisdefinition[GO:0042593]  
1
  • IDABHF-UCL
Maintenance of DNA repeat elementsdefinition[GO:0043570]  
1
  • IMPBHF-UCL
Myoblast fate commitmentdefinition[GO:0048625]  
1
  • IDABHF-UCL
Negative regulation of BMP signaling pathwaydefinition[GO:0030514] silver  
  • IEAOrtholog Compara
Negative regulation of canonical Wnt signaling pathwaydefinition[GO:0090090]  
1
  • IMPUniProtKB
Negative regulation of extrinsic apoptotic signaling pathwaydefinition[GO:2001237]  
1
  • IDABHF-UCL
Negative regulation of fat cell differentiationdefinition[GO:0045599] silver  
  • IEAOrtholog Compara
Negative regulation of fibroblast growth factor receptor signaling pathwaydefinition[GO:0040037] silver  
  • IEAOrtholog Compara
Negative regulation of organ growthdefinition[GO:0046621] silver  
  • IEAOrtholog Compara
Negative regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0043433]  
1
  • IDABHF-UCL
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IDABHF-UCL
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
3
  • IMPUniProtKB
  • IDABHF-UCL
Negative regulation of type B pancreatic cell apoptotic processdefinition[GO:2000675]  
1
  • IDABHF-UCL
Neural tube developmentdefinition[GO:0021915] silver  
  • IEAOrtholog Compara
Odontogenesis of dentin-containing toothdefinition[GO:0042475] silver  
  • IEAOrtholog Compara
Oligodendrocyte developmentdefinition[GO:0014003] silver  
  • IEAOrtholog Compara
Pancreas developmentdefinition[GO:0031016]  
1
  • TASBHF-UCL
Pituitary gland developmentdefinition[GO:0021983] silver  
  • IEAOrtholog Compara
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
  • IEAOrtholog Compara
Positive regulation of epithelial cell proliferationdefinition[GO:0050679] silver  
  • IEAOrtholog Compara
Positive regulation of heparan sulfate proteoglycan biosynthetic processdefinition[GO:0010909]  
1
  • IMPBHF-UCL
Positive regulation of insulin secretiondefinition[GO:0032024]  
2
  • IMPBHF-UCL
Positive regulation of protein bindingdefinition[GO:0032092]  
1
  • IDABHF-UCL
Positive regulation of protein export from nucleusdefinition[GO:0046827]  
1
  • IMPBHF-UCL
Positive regulation of protein kinase B signalingdefinition[GO:0051897]  
1
  • IMPBHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • IDABHF-UCL
Regulation of hormone metabolic processdefinition[GO:0032350]  
1
  • IDABHF-UCL
Regulation of insulin secretion involved in cellular response to glucose stimulusdefinition[GO:0061178] silver  
  • IEAOrtholog Compara
Regulation of myelinationdefinition[GO:0031641] silver  
  • IEAOrtholog Compara
Regulation of oligodendrocyte differentiationdefinition[GO:0048713] silver  
  • IEAOrtholog Compara
Regulation of skeletal muscle tissue developmentdefinition[GO:0048641] silver  
  • IEAOrtholog Compara
Regulation of smooth muscle cell proliferationdefinition[GO:0048660]  
1
  • IMPBHF-UCL
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • IDABHF-UCL
Response to glucosedefinition[GO:0009749]  
1
  • ISSBHF-UCL
Secretory granule localizationdefinition[GO:0032252] silver  
  • IEAOrtholog Compara
Skin developmentdefinition[GO:0043588] silver  
  • IEAOrtholog Compara
Somatic stem cell maintenancedefinition[GO:0035019] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Acute myeloid leukemia  hsa05221+6934  
Adherens junction  hsa04520+6934  
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+6934  
Basal cell carcinoma  hsa05217+6934  
Colorectal cancer  hsa05210+6934  
Endometrial cancer  hsa05213+6934  
Melanogenesis  hsa04916+6934  
Pathways in cancer  hsa05200+6934  
Prostate cancer  hsa05215+6934  
Thyroid cancer  hsa05216+6934  
Wnt signaling pathway  hsa04310+6934  
According to Reactome, this protein belongs to the following pathways:
binding of TCF/LEF:CTNNB1 to target gene promoters  REACT_200799  
Ca2+ pathway  REACT_172761  
deactivation of the beta-catenin transactivating complex  REACT_200731  
formation of the beta-catenin:TCF transactivating complex  REACT_200753  
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)  REACT_24019  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Activator  definition   [KW-0010]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TCF7L2
GenomeRNAi: 6934
PRO: PR:Q9NQB0