RTN4 - Reticulon-4 - human protein (Function)
 
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Protein
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RTN4 »  Reticulon-4
 
Protein also known as:  Neuroendocrine-specific protein C homolog.
Gene name:  RTN4
Entry whose protein(s) existence is based on evidence at protein level
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1 123 6
GENE REF ISO

Function

 show evidences
Overview 
Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity).  
3
  • CuratedUniProtKB
Isoforms  Iso 2 and Iso 3   Inhibit BACE1 activity and amyloid precursor protein processing.  
3
  • CuratedUniProtKB
Isoform  Iso 2   Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration.  
3
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Angiogenesisdefinition[GO:0001525] silver  
  • IEAOrtholog Compara
Apoptotic processdefinition[GO:0006915]  
1
  • NASUniProtKB
Axonal fasciculationdefinition[GO:0007413]  
  • ISSOrtholog Curator
Cardiac epithelial to mesenchymal transitiondefinition[GO:0060317] silver  
  • IEAOrtholog Compara
Cerebral cortex radial glia guided migrationdefinition[GO:0021801]  
  • ISSOrtholog Curator
Endoplasmic reticulum tubular network organizationdefinition[GO:0071786]  
1
  • IMPUniProtKB
Negative regulation of axon extensiondefinition[GO:0030517]  
1
  • IDAUniProtKB
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • IMPDFLAT
Regulation of apoptotic processdefinition[GO:0042981]  
1
  • NASUniProtKB
Regulation of branching morphogenesis of a nervedefinition[GO:2000172]  
  • ISSOrtholog Curator
Isoform  Iso 2   Regulation of cell migrationdefinition[GO:0030334]  
1
  • IDAMGI
Pathways 
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Neurogenesis  definition   [KW-0524]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Reticulon_4
GenomeRNAi: 57142
PRO: PR:Q9NQC3