CYLD - Ubiquitin carboxyl-terminal hydrolase CYLD - human protein (Function)
 
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CYLD »  Ubiquitin carboxyl-terminal hydrolase CYLD   [ EC 3.4.19.12 ]
 
Protein also known as:  Ubiquitin-specific-processing protease CYLD.
Gene name:  CYLD
Family name: Peptidase C19
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 137 2
GENE REF ISO

Function

 show evidences
Overview 
Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation (PubMed12917689, PubMed12917691). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed12917690). Negative regulator of Wnt signaling (PubMed20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed18222923, PubMed20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed17495026, PubMed19893491). Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity).  
12
  • UniProtKB
GO molecular function 
Lys63-specific deubiquitinase activitydefinition[GO:0061578]  
1
  • UniProtKB
Proline-rich region bindingdefinition[GO:0070064]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
6
  • UniProtKB
  • IntAct
Protein kinase bindingdefinition[GO:0019901]  
2
  • UniProtKB
Not  Structural constituent of ribosomedefinition[GO:0003735]  
1
  • RefGenome
Ubiquitin-specific protease activitydefinition[GO:0004843]  
2
  • UniProtKB
Zinc ion bindingdefinition[GO:0008270]  
1
  • UniProtKB
GO biological process 
Cell cycledefinition[GO:0007049]  
1
  • UniProtKB KW
Not  Cytoplasmic translationdefinition[GO:0002181]  
1
  • RefGenome
Necroptotic processdefinition[GO:0070266]  
1
  • RefGenome
Negative regulation of canonical Wnt signaling pathwaydefinition[GO:0090090]  
1
  • UniProtKB
Negative regulation of NF-kappaB import into nucleusdefinition[GO:0042347]  
1
  • UniProtKB
Negative regulation of NF-kappaB transcription factor activitydefinition[GO:0032088]  
1
  • UniProtKB
Positive regulation of extrinsic apoptotic signaling pathwaydefinition[GO:2001238]  
1
  • UniProtKB
Protein K63-linked deubiquitinationdefinition[GO:0070536]  
2
  • UniProtKB
Regulation of cilium assemblydefinition[GO:1902017]  
1
  • Ortholog Curator
Regulation of intrinsic apoptotic signaling pathwaydefinition[GO:2001242]  
1
  • UniProtKB
Regulation of microtubule cytoskeleton organizationdefinition[GO:0070507]  
1
  • UniProtKB
Regulation of mitotic cell cycledefinition[GO:0007346]  
1
  • UniProtKB
Ubiquitin-dependent protein catabolic processdefinition[GO:0006511] silver  
1
  • InterPro 2 GO
Wnt signaling pathwaydefinition[GO:0016055]  
1
  • UniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 3.4.19.12: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).  
2
  • UniProtKB
EC 3.4.19.12: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).  
2
  • UniProtKB
It is regulated in the following manner
Inhibited by phosphorylation at serine residues.  
2
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Osteoclast differentiation  hsa04380+1540  
RIG-I-like receptor signaling pathway  hsa04622+1540  
According to Reactome, this protein belongs to the following pathways:
Negative regulators of RIG-I/MDA5 signaling  REACT_25271  
NOD1/2 Signaling Pathway  REACT_75776  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Ubl conjugation pathway  definition   [KW-0833]
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CYLD_(gene)
GenomeRNAi: 1540
PRO: PR:Q9NQC7