CYLD - Ubiquitin carboxyl-terminal hydrolase CYLD - human protein (Function)
 
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CYLD »  Ubiquitin carboxyl-terminal hydrolase CYLD   [ EC 3.4.19.12 ]
 
Protein also known as:  Ubiquitin-specific-processing protease CYLD.
Gene name:  CYLD
Family name: Peptidase C19
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 125 2
GENE REF ISO

Function

 show evidences
Overview 
Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis. Required for normal cell cycle progress and normal cytokinesis. Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation. Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity).  
12
  • CuratedUniProtKB
GO molecular function 
Lys63-specific deubiquitinase activitydefinition[GO:0061578]  
1
  • IDAUniProtKB
Proline-rich region bindingdefinition[GO:0070064]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIUniProtKB
Protein kinase bindingdefinition[GO:0019901]  
2
  • IPIUniProtKB
Not  Structural constituent of ribosomedefinition[GO:0003735] silver  
  • IBARefGenome
Ubiquitin-specific protease activitydefinition[GO:0004843]  
2
  • IDAUniProtKB
Zinc ion bindingdefinition[GO:0008270]  
1
  • IDAUniProtKB
GO biological process 
Cell cycledefinition[GO:0007049]  
  • IEAUniProtKB KW
Not  Cytoplasmic translationdefinition[GO:0002181] silver  
  • IBARefGenome
Necroptotic processdefinition[GO:0070266] silver  
  • IBARefGenome
Negative regulation of canonical Wnt signaling pathwaydefinition[GO:0090090]  
1
  • IMPUniProtKB
Negative regulation of NF-kappaB import into nucleusdefinition[GO:0042347]  
1
  • IDAUniProtKB
Negative regulation of NF-kappaB transcription factor activitydefinition[GO:0032088]  
1
  • IDAUniProtKB
Positive regulation of extrinsic apoptotic signaling pathwaydefinition[GO:2001238]  
1
  • IMPUniProtKB
Protein K63-linked deubiquitinationdefinition[GO:0070536]  
2
  • IDAUniProtKB
Regulation of intrinsic apoptotic signaling pathwaydefinition[GO:2001242]  
1
  • IMPUniProtKB
Regulation of microtubule cytoskeleton organizationdefinition[GO:0070507]  
1
  • IMPUniProtKB
Regulation of mitotic cell cycledefinition[GO:0007346]  
1
  • IMPUniProtKB
Ubiquitin-dependent protein catabolic processdefinition[GO:0006511] silver  
  • IEAInterPro 2 GO
Wnt signaling pathwaydefinition[GO:0016055]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.19.12: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).  
1
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by phosphorylation at serine residues.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Osteoclast differentiation  hsa04380+1540  
RIG-I-like receptor signaling pathway  hsa04622+1540  
According to Reactome, this protein belongs to the following pathways:
Negative regulators of RIG-I/MDA5 signaling  REACT_25271  
NOD1/2 Signaling Pathway  REACT_75776  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Ubl conjugation pathway  definition   [KW-0833]
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CYLD_(gene)
GenomeRNAi: 1540
PRO: PR:Q9NQC7