G6PC2 - Glucose-6-phosphatase 2 - human protein (Function)
 
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Protein
Gene
References

 
G6PC2 »  Glucose-6-phosphatase 2   [ EC 3.1.3.9 ]  (G6Pase 2)
 
Protein also known as:  Islet-specific glucose-6-phosphatase catalytic subunit-related protein.
Gene name:  G6PC2
Family name: Glucose-6-phosphatase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

 show evidences
Overview 
May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Glucose-6-phosphatase activitydefinition[GO:0004346]  
  • IEAEC 2 GO
GO biological process 
Gluconeogenesisdefinition[GO:0006094]  
  • IEAUniPathway
Glucose homeostasisdefinition[GO:0042593]  
1
  • IMPBHF-UCL
Regulation of insulin secretiondefinition[GO:0050796]  
1
  • IMPBHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.3.9: D-glucose 6-phosphate + H(2)O D-glucose + phosphate.  
1
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Adipocytokine signaling pathway  hsa04920+57818  
Carbohydrate digestion and absorption  hsa04973+57818  
Galactose metabolism  hsa00052+57818  
Glycolysis / Gluconeogenesis  hsa00010+57818  
Insulin signaling pathway  hsa04910+57818  
Metabolic pathways  hsa01100+57818  
Starch and sucrose metabolism  hsa00500+57818  
According to Reactome, this protein belongs to the following pathways:
Metabolism  REACT_111217  
Transmembrane transport of small molecules  REACT_15518  
 
More information is available from:
 

Biophysicochemical properties

Kinetic parameters
KM 0.45 mM for glucose-6-phosphate (at pH 6.5)

Keywords

Biological process 
Gluconeogenesis  definition   [KW-0312]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q9NQR9
Other
GeneWiki: G6PC2
GenomeRNAi: 57818
PRO: PR:Q9NQR9