PAK6 - Serine/threonine-protein kinase PAK 6 - human protein (Function)
 
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PAK6 »  Serine/threonine-protein kinase PAK 6   [ EC 2.7.11.1 ]
 
Protein also known as:  p21-activated kinase 6 (PAK-6).
Gene name:  PAK6
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

 show evidences
Overview 
Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.  
3
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
Receptor signaling protein serine/threonine kinase activitydefinition[GO:0004702]  
1
  • RefGenome
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • UniProtKB
Cytoskeleton organizationdefinition[GO:0007010]  
1
  • UniProtKB
Intracellular signal transductiondefinition[GO:0035556]  
1
  • RefGenome
Not  Mitotic cell cycledefinition[GO:0000278]  
1
  • RefGenome
Protein phosphorylationdefinition[GO:0006468] silver  
1
  • InterPro 2 GO
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • UniProtKB
Signal transduction by protein phosphorylationdefinition[GO:0023014]  
1
  • RefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Axon guidance  hsa04360+56924  
ErbB signaling pathway  hsa04012+56924  
Focal adhesion  hsa04510+56924  
Regulation of actin cytoskeleton  hsa04810+56924  
Renal cell carcinoma  hsa05211+56924  
T cell receptor signaling pathway  hsa04660+56924  
According to Reactome, this protein belongs to the following pathway:
Activation of Rac  REACT_19226  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: PAK6
GenomeRNAi: 56924
PRO: PR:Q9NQU5
Chemistry
GuidetoPHARMACOLOGY: 2137