PRDM5 - PR domain zinc finger protein 5 - human protein (Function)
 
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Protein
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References

 
PRDM5 »  PR domain zinc finger protein 5   [ EC 2.1.1.- ]
 
Protein also known as:  PR domain-containing protein 5.
Gene name:  PRDM5
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May caused G2/M arrest and apoptosis in cancer cells.  
3
  • CuratedUniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Methyltransferase activitydefinition[GO:0008168]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Repressing transcription factor bindingdefinition[GO:0070491]  
1
  • IDAUniProtKB
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • IDAUniProtKB
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • IDAUniProtKB
Transcription regulatory region sequence-specific DNA bindingdefinition[GO:0000976] silver  
  • IEAInterPro 2 GO
GO biological process 
Histone deacetylationdefinition[GO:0016575]  
1
  • IMPUniProtKB
Histone H3-K9 methylationdefinition[GO:0051567]  
1
  • IDAUniProtKB
Mitotic cell cycledefinition[GO:0000278]  
1
  • IMPUniProtKB
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDAUniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Chromatin regulator  definition   [KW-0156]
Methyltransferase  definition   [KW-0489]
Repressor  definition   [KW-0678]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 11107
PRO: PR:Q9NQX1