PRDM5 - PR domain zinc finger protein 5 - human protein (Function)
 
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Protein
Gene
References

 
PRDM5 »  PR domain zinc finger protein 5   [ EC 2.1.1.- ]
 
Protein also known as:  PR domain-containing protein 5.
Gene name:  PRDM5
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May caused G2/M arrest and apoptosis in cancer cells.  
4
  • UniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Methyltransferase activitydefinition[GO:0008168]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Repressing transcription factor bindingdefinition[GO:0070491]  
1
  • UniProtKB
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • NTNU_SB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptiondefinition[GO:0001078]  
1
  • NTNU_SB
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • UniProtKB
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • UniProtKB
GO biological process 
Histone deacetylationdefinition[GO:0016575]  
1
  • UniProtKB
Histone H3-K9 methylationdefinition[GO:0051567]  
1
  • UniProtKB
Mitotic cell cycledefinition[GO:0000278]  
1
  • UniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • NTNU_SB
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • UniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Chromatin regulator  definition   [KW-0156]
Methyltransferase  definition   [KW-0489]
Repressor  definition   [KW-0678]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 11107
PRO: PR:Q9NQX1