POLE4 - DNA polymerase epsilon subunit 4 - human protein (Function)
 
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Protein
Gene
References

 
POLE4 »  DNA polymerase epsilon subunit 4
 
Gene name:  POLE4
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
May play a role in allowing polymerase epsilon to carry out its replication and/or repair function.  
  • CuratedUniProtKB
GO molecular function 
DNA-directed DNA polymerase activitydefinition[GO:0003887]  
  • IEAEC 2 GO
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAInterPro 2 GO
GO biological process 
DNA-dependent DNA replicationdefinition[GO:0006261]  
1
  • TASGOC
  • IEAUniProtKB KW
  • IEAEC 2 GO
Histone H3 acetylationdefinition[GO:0043966]  
1
  • IDABHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.7.7: Deoxynucleoside triphosphate + DNA(n) diphosphate + DNA(n+1).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Base excision repair  hsa03410+56655  
DNA replication  hsa03030+56655  
HTLV-I infection  hsa05166+56655  
Metabolic pathways  hsa01100+56655  
Nucleotide excision repair  hsa03420+56655  
Purine metabolism  hsa00230+56655  
Pyrimidine metabolism  hsa00240+56655  
 

Keywords

Molecular function 
DNA-directed DNA polymerase  definition   [KW-0239]
Nucleotidyltransferase  definition   [KW-0548]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 56655
PRO: PR:Q9NR33