ASH1L - Histone-lysine N-methyltransferase ASH1L - human protein (Function)
 
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ASH1L »  Histone-lysine N-methyltransferase ASH1L   [ EC 2.1.1.43 ]
 
Protein also known as:  Absent small and homeotic disks protein 1 homolog.
Gene name:  ASH1L
Entry whose protein(s) existence is based on evidence at protein level
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1 44 2
GENE REF ISO

Function

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Overview 
Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me).  
1
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
  • IEAInterPro 2 GO
DNA bindingdefinition[GO:0003677] silver  
  • IEAInterPro 2 GO
Histone-lysine N-methyltransferase activitydefinition[GO:0018024]  
  • IEAEC 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
DNA packagingdefinition[GO:0006323]  
1
  • TASPINC
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • IEAUniProtKB KW
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.1.1.43: S-adenosyl-L-methionine + L-lysine-[histone] S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Lysine degradation  hsa00310+55870  
Tight junction  hsa04530+55870  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Chromatin regulator  definition   [KW-0156]
Methyltransferase  definition   [KW-0489]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ASH1L
GenomeRNAi: 55870
PRO: PR:Q9NR48