BATF3 - Basic leucine zipper transcriptional factor ATF-like 3 - human protein (Function)
 
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BATF3 »  Basic leucine zipper transcriptional factor ATF-like 3  (B-ATF-3)
 
Protein also known as:  21 kDa small nuclear factor isolated from T-cells.
Gene name:  BATF3
Family name: bZIP
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes.  
3
  • CuratedUniProtKB
GO molecular function 
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
Transcription corepressor activitydefinition[GO:0003714]  
1
  • TASPINC
GO biological process 
Dendritic cell differentiationdefinition[GO:0097028]  
  • ISSOrtholog Curator
Myeloid dendritic cell differentiationdefinition[GO:0043011]  
  • ISSOrtholog Curator
Response to virusdefinition[GO:0009615]  
  • ISSOrtholog Curator
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • TASPINC
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 55509
PRO: PR:Q9NR55