ARHGEF4 - Rho guanine nucleotide exchange factor 4 - human protein (Function)
 
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Protein
Gene
References

 
ARHGEF4 »  Rho guanine nucleotide exchange factor 4
 
Protein also known as:  APC-stimulated guanine nucleotide exchange factor 1 (Asef).
Gene name:  ARHGEF4
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.  
5
  • CuratedUniProtKB
GO molecular function 
Guanyl-nucleotide exchange factor activitydefinition[GO:0005085]  
1
  • IMPUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein domain specific bindingdefinition[GO:0019904]  
1
  • IPIUniProtKB
Rac guanyl-nucleotide exchange factor activitydefinition[GO:0030676]  
1
  • IMPUniProtKB
GO biological process 
Filopodium assemblydefinition[GO:0046847]  
1
  • IMPUniProtKB
Lamellipodium assemblydefinition[GO:0030032]  
1
  • IMPUniProtKB
Positive regulation of GTPase activitydefinition[GO:0043547]  
1
  • IMPGOC
Positive regulation of Rac GTPase activitydefinition[GO:0032855]  
1
  • IMPGOC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Regulation of actin cytoskeleton  hsa04810+50649  
According to Reactome, this protein belongs to the following pathways:
G alpha (12/13) signalling events  REACT_18407  
NRAGE signals death through JNK  REACT_13638  
Rho GTPase cycle  REACT_11051  
 

Keywords

Molecular function 
Guanine-nucleotide releasing factor  definition   [KW-0344]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ARHGEF4
GenomeRNAi: 50649
PRO: PR:Q9NR80