KCNQ5 - Potassium voltage-gated channel subfamily KQT member 5 - human protein (Function)
 
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Protein
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References

 
KCNQ5 »  Potassium voltage-gated channel subfamily KQT member 5
 
Protein also known as:  Voltage-gated potassium channel subunit Kv7.5.
Gene name:  KCNQ5
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 37 5
GENE REF ISO

Function

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Overview 
Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1) muscarinic receptors.  
  • CuratedUniProtKB
GO molecular function 
Delayed rectifier potassium channel activitydefinition[GO:0005251] silver  
  • IBARefGenome
Inward rectifier potassium channel activitydefinition[GO:0005242]  
1
  • TASPINC
GO biological process 
Protein complex assemblydefinition[GO:0006461]  
1
  • NASPINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Cholinergic synapse  hsa04725+56479  
According to Reactome, this protein belongs to the following pathway:
Neuronal System  REACT_13685  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Potassium channel  definition   [KW-0631]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KCNQ5
GenomeRNAi: 56479
PRO: PR:Q9NR82
Chemistry
GuidetoPHARMACOLOGY: 564