PDGFC - Platelet-derived growth factor C - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
PDGFC »  Platelet-derived growth factor C  (PDGF-C)
 
Protein also known as:  Spinal cord-derived growth factor (SCDGF). Cleaved into:  Platelet-derived growth factor C, latent form; Platelet-derived growth factor C, receptor-binding form.
Gene name:  PDGFC
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 60 4
GENE REF ISO

Function

 show evidences
Overview 
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.  
12
  • CuratedUniProtKB
GO molecular function 
Growth factor activitydefinition[GO:0008083]  
  • IEAUniProtKB KW
Platelet-derived growth factor receptor bindingdefinition[GO:0005161]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIBHF-UCL
GO biological process 
Activation of transmembrane receptor protein tyrosine kinase activitydefinition[GO:0007171] silver  
  • IEAOrtholog Compara
Cellular response to amino acid stimulusdefinition[GO:0071230] silver  
  • IEAOrtholog Compara
Central nervous system developmentdefinition[GO:0007417]  
1
  • TASUniProtKB
Organ morphogenesisdefinition[GO:0009887] silver  
  • IEAOrtholog Compara
Platelet-derived growth factor receptor signaling pathwaydefinition[GO:0048008]  
1
  • IDABHF-UCL
Positive regulation of cell divisiondefinition[GO:0051781]  
  • IEAUniProtKB KW
Positive regulation of DNA replicationdefinition[GO:0045740]  
1
  • IDABHF-UCL
Positive regulation of fibroblast proliferationdefinition[GO:0048146]  
1
  • IDABHF-UCL
Regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050730] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+56034  
Focal adhesion  hsa04510+56034  
Gap junction  hsa04540+56034  
Melanoma  hsa05218+56034  
Prostate cancer  hsa05215+56034  
Regulation of actin cytoskeleton  hsa04810+56034  
According to Reactome, this protein belongs to the following pathway:
Signaling by PDGF  REACT_16888  
Note 
A lower molecular weight form (around 43 kDa) is present in patients with papillary thyroid carcinoma.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Developmental protein  definition   [KW-0217]
Growth factor  definition   [KW-0339]
Mitogen  definition   [KW-0497]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PDGFC
GenomeRNAi: 56034
PRO: PR:Q9NRA1