SLC17A5 - Sialin - human protein (Function)
 
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Protein
Gene
References

 
SLC17A5 »  Sialin
 
Protein also known as:  Vesicular H(+)/Aspartate-glutamate cotransporter.
Gene name:  SLC17A5
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 35 2
GENE REF ISO

Function

 show evidences
Overview 
Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential-dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva.  
5
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the major facilitator superfamily (mfs)  2.A.1.14.10  
GO molecular function 
Sialic acid transmembrane transporter activitydefinition[GO:0015136]  
1
  • IDAMGI
Sugar:proton symporter activitydefinition[GO:0005351]  
1
  • TASPINC
GO biological process 
Amino acid transportdefinition[GO:0006865]  
  • IEAUniProtKB KW
Anion transportdefinition[GO:0006820]  
1
  • TASPINC
Proton transportdefinition[GO:0015992]  
1
  • TASGOC
Sialic acid transportdefinition[GO:0015739]  
1
  • IDAMGI
Pathways 
According to KEGG, this protein belongs to the following pathway:
Lysosome  hsa04142+26503  
According to Reactome, this protein belongs to the following pathways:
Organic anion transporters  REACT_19372  
Sialic acid metabolism  REACT_200874  
 

Keywords

Biological process 
Amino-acid transport  definition   [KW-0029]
Symport  definition   [KW-0769]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: HP59
GeneWiki: SLC17A5
GenomeRNAi: 26503
PRO: PR:Q9NRA2