SIRT7 - NAD-dependent protein deacetylase sirtuin-7 - human protein (Function)
 
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SIRT7 »  NAD-dependent protein deacetylase sirtuin-7   [ EC 3.5.1.- ]
 
Protein also known as:  Regulatory protein SIR2 homolog 7.
Gene name:  SIRT7
Family name: Sirtuin » Class IV
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.  
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  • UniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682]  
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  • UniProtKB
Metal ion bindingdefinition[GO:0046872]  
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  • UniProtKB KW
NAD+ bindingdefinition[GO:0070403] silver  
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  • InterPro 2 GO
NAD-dependent histone deacetylase activity (H3-K18 specific)definition[GO:0097372]  
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  • UniProtKB
Protein bindingdefinition[GO:0005515]  
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  • UniProtKB
GO biological process 
Histone H3 deacetylationdefinition[GO:0070932]  
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  • UniProtKB
Histone H4 deacetylationdefinition[GO:0070933]  
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  • GOC
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
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  • UniProtKB
Positive regulation of transcription on exit from mitosisdefinition[GO:0007072]  
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  • UniProtKB
rRNA transcriptiondefinition[GO:0009303]  
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  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.5.1.-: NAD(+) + an acetylprotein nicotinamide + O-acetyl-ADP-ribose + a protein.  
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  • UniProtKB
  • PROSITE-ProRule
It requires the following cofactor
 Zn(2+) : Binds 1 zinc ion per subunit.  
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  • UniProtKB
Note 
Overexpressed in human thyroid carcinoma cell lines and tissues, but not in adenomas.  
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  • UniProtKB
Caution 
Was originally (PubMed11953824) termed SIR-T8/SIRT8. This was later retracted (PubMed:12454780). See also PubMed:12454781.  
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  • UniProtKB
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Chromatin regulator  definition   [KW-0156]
Hydrolase  definition   [KW-0378]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SIRT7
GenomeRNAi: 51547
PRO: PR:Q9NRC8