DUOX2 - Dual oxidase 2 - human protein (Function)
 
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DUOX2 »  Dual oxidase 2   [ EC 1.6.3.1EC 1.11.1.- ]
 
Protein also known as:  NADH/NADPH thyroid oxidase p138-tox.
Gene name:  DUOX2
Family name: In the N-terminal section Peroxidase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the phagocyte (gp91(phox)) nadph oxidase family  5.B.1.2.2  
GO molecular function 
Calcium ion bindingdefinition[GO:0005509]  
1
  • IDAUniProtKB
Heme bindingdefinition[GO:0020037] silver  
  • IEAInterPro 2 GO
NAD(P)H oxidase activitydefinition[GO:0016174]  
1
  • IDAUniProtKB
Peroxidase activitydefinition[GO:0004601]  
  • IEAUniProtKB KW
GO biological process 
Cuticle developmentdefinition[GO:0042335]  
  • ISSOrtholog Curator
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Hormone biosynthetic processdefinition[GO:0042446]  
  • IEAUniProtKB KW
Hydrogen peroxide catabolic processdefinition[GO:0042744]  
  • IEAUniProtKB KW
Oxidation-reduction processdefinition[GO:0055114]  
1
  • TASUniProtKB
Response to cAMPdefinition[GO:0051591]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Response to virusdefinition[GO:0009615]  
1
  • IDAUniProtKB
Thyroid hormone generationdefinition[GO:0006590]  
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.6.3.1: NAD(P)H + O(2) NAD(P)(+) + H(2)O(2).  
1
  • CuratedUniProtKB
It is regulated in the following manner
Peroxidase activity is inhibited by aminobenzohydrazide (By similarity). The NADPH oxidase activity is calcium-dependent.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
 

Keywords

Biological process 
Hydrogen peroxide  definition   [KW-0376]
Thyroid hormones biosynthesis  definition   [KW-0893]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Peroxidase  definition   [KW-0575]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q9NRD8
Other
GeneWiki: Dual_oxidase_2
GenomeRNAi: 50506
PRO: PR:Q9NRD8