CTPS2 - CTP synthase 2 - human protein (Function)
 
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Protein
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References

 
CTPS2 »  CTP synthase 2   [ EC 6.3.4.2 ]
 
Protein also known as:  UTP--ammonia ligase 2.
Gene name:  CTPS2
Family name: CTP synthase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides.  
2
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
GO biological process 
'de novo' CTP biosynthetic processdefinition[GO:0044210]  
  • IEAUniPathway
Glutamine metabolic processdefinition[GO:0006541]  
  • IEAUniProtKB KW
Pyrimidine nucleotide metabolic processdefinition[GO:0006220]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.3.4.2: ATP + UTP + L-glutamine ADP + phosphate + CTP + L-glutamate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+56474  
Pyrimidine metabolism  hsa00240+56474  
According to Reactome, this protein belongs to the following pathway:
Synthesis and interconversion of nucleotide di- and triphosphates  REACT_21330  
 
More information is available from:
 

Keywords

Biological process 
Pyrimidine biosynthesis  definition   [KW-0665]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CTPS2
GenomeRNAi: 56474
PRO: PR:Q9NRF8