BAZ1A - Bromodomain adjacent to zinc finger domain protein 1A - human protein (Function)
 
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BAZ1A »  Bromodomain adjacent to zinc finger domain protein 1A
 
Protein also known as:  Williams syndrome transcription factor-related chromatin-remodeling factor 180 (WCRF180).
Gene name:  BAZ1A
Family name: WAL
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end-positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression.  
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  • CuratedUniProtKB
Component of the histone-fold protein complex CHRAC complex which faciliates nucleosome sliding by the ACF complex and enhances ACF-mediated chromatin assembly. The C-terminal regions of both CHRAC1 and POLE1 are required for these functions.  
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  • CuratedUniProtKB
GO molecular function 
Not  Histone acetyltransferase activitydefinition[GO:0004402]  
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  • TASBHF-UCL
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
  • IPIIntAct
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Chromatin remodelingdefinition[GO:0006338]  
1
  • TASBHF-UCL
DNA-dependent DNA replicationdefinition[GO:0006261]  
1
  • IDAUniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • NASBHF-UCL
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • NASBHF-UCL
Note 
Stimulated by double-stranded DNA and nucleosomal DNA.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 11177
PRO: PR:Q9NRL2