AASDHPPT - L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase - human protein (Function)
 
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Protein
Gene
References

 
AASDHPPT »  L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase   [ EC 2.7.8.- ]
 
Protein also known as:  Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase (AASD-PPT).
Gene name:  AASDHPPT
Family name: P-Pant transferase » AcpS
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 27 1
GENE REF ISO

Function

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Overview 
Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN.  
3
  • CuratedUniProtKB
GO molecular function 
Holo-[acyl-carrier-protein] synthase activitydefinition[GO:0008897]  
1
  • IDAUniProtKB
Magnesium ion bindingdefinition[GO:0000287]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Macromolecule biosynthetic processdefinition[GO:0009059] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.8.-: CoA-[4'-phosphopantetheine] + apo-[acyl-carrier-protein] adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 magnesium ion.  
2
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Pantothenate and CoA biosynthesis  hsa00770+60496  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Metabolism  REACT_111217  
 
More information is available from:
 

Biophysicochemical properties

Kinetic parameters
KM 0.44 mM for magnesium
KM 0.025 mM for coenzyme A

Keywords

Molecular function 
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q9NRN7
Other
GeneWiki: AASDHPPT
GenomeRNAi: 60496
PRO: PR:Q9NRN7