PLSCR4 - Phospholipid scramblase 4 - human protein (Function)
 
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PLSCR4 »  Phospholipid scramblase 4  (PL scramblase 4)
 
Protein also known as:  Ca(2+)-dependent phospholipid scramblase 4.
Gene name:  PLSCR4
Entry whose protein(s) existence is based on evidence at protein level
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1 24 2
GENE REF ISO

Function

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Overview 
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.  
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509]  
1
  • NASUniProtKB
CD4 receptor bindingdefinition[GO:0042609]  
1
  • IPIUniProtKB
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
Phospholipid scramblase activitydefinition[GO:0017128]  
1
  • NASUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
SH3 domain bindingdefinition[GO:0017124]  
  • IEAUniProtKB KW
GO biological process 
Cellular response to lipopolysaccharidedefinition[GO:0071222] silver  
  • IEAOrtholog Compara
Phospholipid scramblingdefinition[GO:0017121]  
1
  • NASUniProtKB
Enzymatic activity 
It requires the following cofactor
Calcium or magnesium.  
1
  • CuratedUniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PLSCR4
GenomeRNAi: 57088
PRO: PR:Q9NRQ2