CHST7 - Carbohydrate sulfotransferase 7 - human protein (Function)
 
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CHST7 »  Carbohydrate sulfotransferase 7   [ EC 2.8.2.-EC 2.8.2.17 ]
 
Protein also known as:  Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 5 (GST-5).
Gene name:  CHST7
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 13 1
GENE REF ISO

Function

 show evidences
Overview 
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc.  
3
  • CuratedUniProtKB
GO molecular function 
Chondroitin 6-sulfotransferase activitydefinition[GO:0008459]  
1
  • IDAUniProtKB
N-acetylglucosamine 6-O-sulfotransferase activitydefinition[GO:0001517]  
1
  • IDAUniProtKB
GO biological process 
Chondroitin sulfate biosynthetic processdefinition[GO:0030206]  
1
  • IDAUniProtKB
N-acetylglucosamine metabolic processdefinition[GO:0006044]  
1
  • IDAUniProtKB
Polysaccharide metabolic processdefinition[GO:0005976]  
1
  • TASUniProtKB
Sulfur compound metabolic processdefinition[GO:0006790]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.8.2.17: 3'-phosphoadenylyl sulfate + chondroitin adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Glycosaminoglycan biosynthesis - chondroitin sulfate  hsa00532+56548  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Carbohydrate metabolism  definition   [KW-0119]
Molecular function 
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q9NS84
Other
GeneWiki: CHST7
GenomeRNAi: 56548
PRO: PR:Q9NS84