CISH - Cytokine-inducible SH2-containing protein - human protein (Function)
 
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CISH »  Cytokine-inducible SH2-containing protein  (CIS)
 
Protein also known as:  Suppressor of cytokine signaling (SOCS).
Gene name:  CISH
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 34 3
GENE REF ISO

Function

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Overview 
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).  
1
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
Protein kinase inhibitor activitydefinition[GO:0004860]  
1
  • RefGenome
GO biological process 
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
1
  • RefGenome
Intracellular signal transductiondefinition[GO:0035556]  
1
  • UniProtKB
Negative regulation of insulin receptor signaling pathwaydefinition[GO:0046627]  
1
  • RefGenome
Negative regulation of JAK-STAT cascadedefinition[GO:0046426]  
1
  • RefGenome
Negative regulation of protein kinase activitydefinition[GO:0006469]  
1
  • RefGenome
Protein kinase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007205] silver  
1
  • Ortholog Compara
Protein ubiquitinationdefinition[GO:0016567]  
1
  • UniPathway
Regulation of cell growthdefinition[GO:0001558]  
1
  • UniProtKB
Pathways 
This protein is involved in the following pathway
Protein modification; protein ubiquitination  
1
  • UniProtKB
According to KEGG, this protein belongs to the following pathway:
Jak-STAT signaling pathway  hsa04630+1154  
According to Reactome, this protein belongs to the following pathway:
Growth hormone receptor signaling  REACT_111133  
 

Keywords

Biological process 
Growth regulation  definition   [KW-0341]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Signal transduction inhibitor  definition   [KW-0734]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CISH
GenomeRNAi: 1154
PRO: PR:Q9NSE2