ATG3 - Ubiquitin-like-conjugating enzyme ATG3 - human protein (Function)
 
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ATG3 »  Ubiquitin-like-conjugating enzyme ATG3   [ EC 6.3.2.- ]
 
Protein also known as:  Autophagy-related protein 3 (APG3-like).
Gene name:  ATG3
Family name: ATG3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.  
5
  • CuratedUniProtKB
GO molecular function 
Atg12 ligase activitydefinition[GO:0019777]  
  • ISSOrtholog Curator
Atg8 ligase activitydefinition[GO:0019776]  
  • ISSOrtholog Curator
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIUniProtKB
Small conjugating protein ligase activitydefinition[GO:0019787]  
1
  • IDAMGI
GO biological process 
Autophagic vacuole assemblydefinition[GO:0000045]  
  • ISSOrtholog Curator
Cellular protein modification processdefinition[GO:0006464]  
1
  • IDAMGI
Mitochondrial fragmentation involved in apoptotic processdefinition[GO:0043653]  
  • ISSOrtholog Curator
Protein targeting to membranedefinition[GO:0006612]  
  • ISSOrtholog Curator
Protein ubiquitinationdefinition[GO:0016567]  
1
  • IDAUniProtKB
Regulation of cilium assemblydefinition[GO:1902017]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathway:
Regulation of autophagy  hsa04140+64422  
 

Keywords

Biological process 
Autophagy  definition   [KW-0072]
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 64422
PRO: PR:Q9NT62