SIRT3 - NAD-dependent protein deacetylase sirtuin-3, mitochondrial - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
SIRT3 »  NAD-dependent protein deacetylase sirtuin-3, mitochondrial   [ EC 3.5.1.- ]
 
Protein also known as:  Regulatory protein SIR2 homolog 3.
Gene name:  SIRT3
Family name: Sirtuin » Class I
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 70 2
GENE REF ISO

Function

 show evidences
Overview 
NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins, including ACSS1, IDH, GDH and LCAD by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.  
5
  • CuratedUniProtKB
GO molecular function 
Not  NAD+ ADP-ribosyltransferase activitydefinition[GO:0003950]  
1
  • TASBHF-UCL
NAD+ bindingdefinition[GO:0070403] silver  
  • IEAInterPro 2 GO
NAD-dependent histone deacetylase activity (H3-K14 specific)definition[GO:0032041] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIUniProtKB
Zinc ion bindingdefinition[GO:0008270]  
1
  • IDAUniProtKB
GO biological process 
Aerobic respirationdefinition[GO:0009060]  
1
  • IMPUniProtKB
Peptidyl-lysine deacetylationdefinition[GO:0034983]  
1
  • IMPUniProtKB
Not  Protein ADP-ribosylationdefinition[GO:0006471]  
1
  • TASBHF-UCL
Protein deacetylationdefinition[GO:0006476]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.5.1.-: NAD(+) + an acetylprotein nicotinamide + O-acetyl-ADP-ribose + a protein.  
3
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 zinc ion per subunit.  
  • CuratedUniProtKB
Note 
Has some ability to deacetylate histones in vitro, but seeing its subcellular location, this is unlikely in vivo.  
  • CuratedUniProtKB
 

Biophysicochemical properties

Kinetic parameters
KM 600 uM for NAD

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SIRT3
GenomeRNAi: 23410
PRO: PR:Q9NTG7