SIRT3 - NAD-dependent protein deacetylase sirtuin-3, mitochondrial - human protein (Function)
 
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SIRT3 »  NAD-dependent protein deacetylase sirtuin-3, mitochondrial   [ EC 3.5.1.- ]
 
Protein also known as:  Regulatory protein SIR2 homolog 3.
Gene name:  SIRT3
Family name: Sirtuin » Class I
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.  
7
  • UniProtKB
GO molecular function 
Enzyme bindingdefinition[GO:0019899] silver  
1
  • Ortholog Compara
Not  NAD+ ADP-ribosyltransferase activitydefinition[GO:0003950]  
1
  • BHF-UCL
NAD+ bindingdefinition[GO:0070403] silver  
1
  • InterPro 2 GO
NAD-dependent histone deacetylase activity (H3-K14 specific)definition[GO:0032041] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
  • UniProtKB
Zinc ion bindingdefinition[GO:0008270]  
1
  • UniProtKB
GO biological process 
Aerobic respirationdefinition[GO:0009060]  
1
  • UniProtKB
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Histone H3 deacetylationdefinition[GO:0070932] silver  
1
  • Ortholog Compara
Peptidyl-lysine deacetylationdefinition[GO:0034983]  
1
  • UniProtKB
Not  Protein ADP-ribosylationdefinition[GO:0006471]  
1
  • BHF-UCL
Protein deacetylationdefinition[GO:0006476]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.5.1.-: NAD(+) + an acetylprotein nicotinamide + O-acetyl-ADP-ribose + a protein.  
5
  • UniProtKB
  • PROSITE-ProRule
It requires the following cofactor
 Zn(2+) : Binds 1 zinc ion per subunit.  
1
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Transcriptional activation of mitochondrial biogenesis  REACT_200608  
Note 
Has some ability to deacetylate histones in vitro, but seeing its subcellular location, this is unlikely in vivo.  
1
  • UniProtKB
 

Biophysicochemical properties

Kinetic parameters
KM 600 uM for NAD

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SIRT3
GenomeRNAi: 23410
PRO: PR:Q9NTG7