ATP8A2 - Phospholipid-transporting ATPase IB - human protein (Function)
 
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ATP8A2 »  Phospholipid-transporting ATPase IB   [ EC 3.6.3.1 ]
 
Protein also known as:  P4-ATPase flippase complex alpha subunit ATP8A2.
Gene name:  ATP8A2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Involved in regulation of neurite outgrowth; acting in synergy with TMEM30A. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival.  
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  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Magnesium ion bindingdefinition[GO:0000287] silver  
1
  • InterPro 2 GO
Phospholipid-translocating ATPase activitydefinition[GO:0004012]  
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  • RefGenome
GO biological process 
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Axonogenesisdefinition[GO:0007409] silver  
1
  • Ortholog Compara
Detection of light stimulus involved in visual perceptiondefinition[GO:0050908] silver  
1
  • Ortholog Compara
Eating behaviordefinition[GO:0042755] silver  
1
  • Ortholog Compara
Inner ear morphogenesisdefinition[GO:0042472] silver  
1
  • Ortholog Compara
Involuntary skeletal muscle contractiondefinition[GO:0003011] silver  
1
  • Ortholog Compara
Metabolic processdefinition[GO:0008152]  
1
  • UniProtKB KW
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • PINC
Neurofilament cytoskeleton organizationdefinition[GO:0060052] silver  
1
  • Ortholog Compara
Neuromuscular process controlling posturedefinition[GO:0050884] silver  
1
  • Ortholog Compara
Neuron developmentdefinition[GO:0048666]  
1
  • RefGenome
Phospholipid translocationdefinition[GO:0045332]  
1
  • RefGenome
Positive regulation of multicellular organism growthdefinition[GO:0040018] silver  
1
  • Ortholog Compara
Positive regulation of neuron projection developmentdefinition[GO:0010976] silver  
1
  • Ortholog Compara
Positive regulation of phospholipid translocationdefinition[GO:0061092] silver  
1
  • Ortholog Compara
Response to auditory stimulusdefinition[GO:0010996] silver  
1
  • Ortholog Compara
Retina layer formationdefinition[GO:0010842] silver  
1
  • Ortholog Compara
Skin developmentdefinition[GO:0043588] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.3.1: ATP + H(2)O + phospholipid(Side 1) ADP + phosphate + phospholipid(Side 2).  
1
  • UniProtKB
It is regulated in the following manner
ATPase activity is stimulated by phosphatidylserine (PS) and minimally by phosphatidylethanolamine (PE). ATPase activity is inhibited by N-ethylmaleimide (NEM) and vanadate. Flippase activity is inhibited by NEM and 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS) (By similarity).  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Ion transport by P-type ATPases  REACT_25149  
 

Keywords

Biological process 
Lipid transport  definition   [KW-0445]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 51761
PRO: PR:Q9NTI2