ATP8A2 - Phospholipid-transporting ATPase IB - human protein (Function)
 
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ATP8A2 »  Phospholipid-transporting ATPase IB   [ EC 3.6.3.1 ]
 
Protein also known as:  P4-ATPase flippase complex alpha subunit ATP8A2.
Gene name:  ATP8A2
Entry whose protein(s) existence is based on evidence at protein level
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1 27 2
GENE REF ISO

Function

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Overview 
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Involved in regulation of neurite outgrowth; acting in synergy with TMEM30A. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Cation-transporting ATPase activitydefinition[GO:0019829] silver  
  • IEAInterPro 2 GO
Magnesium ion bindingdefinition[GO:0000287] silver  
  • IEAInterPro 2 GO
Phospholipid-translocating ATPase activitydefinition[GO:0004012]  
  • IEAEC 2 GO
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Axonogenesisdefinition[GO:0007409] silver  
  • IEAOrtholog Compara
Cation transportdefinition[GO:0006812] silver  
  • IEAInterPro 2 GO
Eating behaviordefinition[GO:0042755] silver  
  • IEAOrtholog Compara
Involuntary skeletal muscle contractiondefinition[GO:0003011] silver  
  • IEAOrtholog Compara
Metabolic processdefinition[GO:0008152]  
  • IEAUniProtKB KW
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • TASPINC
Neuromuscular process controlling posturedefinition[GO:0050884] silver  
  • IEAOrtholog Compara
Phospholipid translocationdefinition[GO:0045332]  
  • IEAEC 2 GO
  • IEAInterPro 2 GO
Positive regulation of multicellular organism growthdefinition[GO:0040018] silver  
  • IEAOrtholog Compara
Skin developmentdefinition[GO:0043588] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.3.1: ATP + H(2)O + phospholipid(Side 1) ADP + phosphate + phospholipid(Side 2).  
  • CuratedUniProtKB
It is regulated in the following manner
ATPase activity is stimulated by phosphatidylserine (PS) and minimally by phosphatidylethanolamine (PE). ATPase activity is inhibited by N-ethylmaleimide (NEM) and vanadate. Flippase activity is inhibited by NEM and 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS) (By similarity).  
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Ion transport by P-type ATPases  REACT_25149  
 

Keywords

Biological process 
Lipid transport  definition   [KW-0445]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 51761
PRO: PR:Q9NTI2