ECHDC1 - Ethylmalonyl-CoA decarboxylase - human protein (Function)
 
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Protein
Gene
References

 
ECHDC1 »  Ethylmalonyl-CoA decarboxylase   [ EC 4.1.1.94 ]
 
Protein also known as:  Enoyl-CoA hydratase domain-containing protein 1.
Gene name:  ECHDC1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level.  
1
  • CuratedUniProtKB
GO molecular function 
Carboxy-lyase activitydefinition[GO:0016831]  
  • ISSOrtholog Curator
Methylmalonyl-CoA decarboxylase activitydefinition[GO:0004492]  
  • IEAEC 2 GO
GO biological process 
Metabolic processdefinition[GO:0008152] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 4.1.1.94: (S)-ethylmalonyl-CoA butanoyl-CoA + CO(2).  
  • CuratedUniProtKB
EC 4.1.1.41: (S)-methylmalonyl-CoA propanoyl-CoA + CO(2).  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 55862
PRO: PR:Q9NTX5