RNF146 - E3 ubiquitin-protein ligase RNF146 - human protein (Function)
 
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RNF146 »  E3 ubiquitin-protein ligase RNF146   [ EC 6.3.2.- ]
 
Protein also known as:  RING finger protein 146.
Gene name:  RNF146
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation. Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48'. May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location. Neuroprotective protein. Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos. Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner. Does not affect PARP1 activation (By similarity). Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest. Promotes cell survival after gamma-irradiation. Facilitates DNA repair.  
5
  • CuratedUniProtKB
GO molecular function 
Poly-ADP-D-ribose bindingdefinition[GO:0072572]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Ubiquitin-protein ligase activitydefinition[GO:0004842]  
1
  • IDAUniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Positive regulation of canonical Wnt signaling pathwaydefinition[GO:0090263]  
1
  • IMPUniProtKB
Protein autoubiquitinationdefinition[GO:0051865]  
1
  • IDAUniProtKB
Protein K48-linked ubiquitinationdefinition[GO:0070936]  
1
  • IMPUniProtKB
Protein ubiquitination involved in ubiquitin-dependent protein catabolic processdefinition[GO:0042787]  
1
  • IMPUniProtKB
Wnt signaling pathwaydefinition[GO:0016055]  
  • IEAUniProtKB KW
Pathways 
This protein is involved in the following pathway
Note 
Was named dactylidin after the Greek term 'daktylidi' for ring, 'the thing around the finger' (PubMed15813938). Was named Iduna after the Norse goddess of protection and eternal youth (PubMed21602803).  
2
  • CuratedUniProtKB
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RNF146
GenomeRNAi: 81847
PRO: PR:Q9NTX7