ZFP57 - Zinc finger protein 57 homolog - human protein (Function)
 
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ZFP57 »  Zinc finger protein 57 homolog  (Zfp-57)
 
Protein also known as:  Zinc finger protein 698.
Gene name:  ZFP57
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element (By similarity). Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells.  
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  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
DNA methylation involved in embryo developmentdefinition[GO:0043045]  
1
  • IMPUniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Peripheral nervous system developmentdefinition[GO:0007422] silver  
  • IEAOrtholog Compara
Regulation of gene expression by genetic imprintingdefinition[GO:0006349]  
1
  • IMPUniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ZFP57
GenomeRNAi: 346171
PRO: PR:Q9NU63