ZFP57 - Zinc finger protein 57 homolog - human protein (Sequence)
 
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Protein
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ZFP57 »  Zinc finger protein 57 homolog  (Zfp-57)
 
Protein also known as:  Zinc finger protein 698.
Gene name:  ZFP57
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 21 3
GENE REF ISO

Displayed isoform: Iso 1     

 
 
Isoform Iso 1   452 aaMass: 51919 Da,  pI: 9.34
MAAGEPRSLL FFQKPVTFED VAVNFTQEEW DCLDASQRVL YQDVMSETFK NLTSVARIFL HKPELITKLE QEEEQWRETR VLQASQAGPP FFCYTCGKCF SRRSYLYSHQ FVHNPKLTNS CSQCGKLFRS PKSLSYHRRM HLGERPFCCT LCDKTYCDAS GLSRHRRVHL GYRPHSCSVC GKSFRDQSEL KRHQKIHQNQ EPVDGNQECT LRIPGTQAEF QTPIARSQRS IQGLLDVNHA PVARSQEPIF RTEGPMAQNQ ASVLKNQAPV TRTQAPITGT LCQDARSNSH PVKPSRLNVF CCPHCSLTFS KKSYLSRHQK AHLTEPPNYC FHCSKSFSSF SRLVRHQQTH WKQKSYLCPI CDLSFGEKEG LMDHWRGYKG KDLCQSSHHK CRVILGQWLG FSHDVPTMAG EEWKHGGDQS PPRIHTPRRR GLREKACKGD KTKEAVSILK HK

Sequence

 show evidences
Domain 
The KRAB domain is required for function as transcriptional repressor (By similarity).  
  • CuratedUniProtKB
Zinc fingers 3 and 4 mediate recognition of the target element, ZF3 interacting with the 5' half (TGC) and ZF4 interacting with the 3' half (CGC) (By similarity).  
  • CuratedUniProtKB
Sequence caution 
The sequence CAQ10094 differs from that shown. Reason: erroneous gene model prediction.  
  • CuratedUniProtKB
 

Keywords

Coding sequence diversity 
Alternative splicing  definition   [KW-0025]
Polymorphism  definition   [KW-0621]
Domain 
Repeat  definition   [KW-0677]
Zinc-finger  definition   [KW-0863]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Family and domain databases
Gene3D: 3.30.160.60
InterPro: IPR007087 [ Znf C2H2 ]
InterPro: IPR001909 [ Krueppel-associated box ]
InterPro: IPR013087 [ Znf C2H2/integrase DNA-bd ]
InterPro: IPR015880 [ Znf C2H2-like ]
Pfam: PF00096 [ zf-C2H2 ]
Pfam: PF01352 [ KRAB ]
PROSITE: PS50157 [ ZINC FINGER C2H2 2 ]
PROSITE: PS00028 [ ZINC FINGER C2H2 1 ]
PROSITE: PS50805 [ KRAB ]
SMART: SM00355 [ ZnF C2H2 ]
SMART: SM00349 [ KRAB ]
SUPFAM: SSF109640 [ SSF109640 ]
Genome annotation databases
Ensembl: Transcript: ENST00000376883;  Protein: ENSP00000366080;  Gene: ENSG00000204644.
Ensembl: Transcript: ENST00000488757;  Protein: ENSP00000418259;  Gene: ENSG00000204644.
Ensembl: Transcript: ENST00000376881;  Protein: ENSP00000366078;  Gene: ENSG00000204644.
KEGG: hsa:346171
UCSC: uc011dlw.2
Organism-specific databases
MGI: MGI:99204 [ Zfp57 ]
PTM databases
PhosphoSite: Q9NU63
Phylogenomic databases
eggNOG: NOG267305
HOGENOM: HOG000155778
HOVERGEN: HBG108764
KO: K09228
OMA: LLDVNHA
OrthoDB: EOG7KM5S9
PhylomeDB: Q9NU63
Sequence databases
CCDS: CCDS43436.2 [ Q9NU63-3 ]
EMBL: mRNA:  BC157878 . Translation:  AAI57879.1 .
EMBL: Genomic DNA:  BX120002 . Translation:  CAI95569.2 .
EMBL: Genomic DNA:  AL929591 . Translation:  CAI41919.2 .
EMBL: Genomic DNA:  CR936483 . Translation:  CAQ10094.1 . Sequence problems.
EMBL: Genomic DNA:  AL645936 . Translation:  CAI18028.2 .
EMBL: Genomic DNA:  CR759766 . Translation:  CAQ06621.1 .
EMBL: Genomic DNA:  AL669813 . Translation:  CAI17624.2 .
EMBL: Genomic DNA:  AL050328 . Translation:  CAB89275.2 .
EMBL: Genomic DNA:  BX927250 . Translation:  CAQ10717.1 .
EMBL: Genomic DNA:  CR388408 . Translation:  CAQ08216.1 .
IPI: IPI00642672
IPI: IPI00646777
IPI: IPI00923474
RefSeq: Protein:  XP_006725548.1. Nucleotide sequence:  XM_006725485.1.
RefSeq: Protein:  XP_006725549.1. Nucleotide sequence:  XM_006725486.1.
RefSeq: Protein:  NP_001103279.2. Nucleotide sequence:  NM_001109809.2.
UniProtKB: Q9NU63
Protocols and materials databases
DNASU: 346171