ACSS1 - Acetyl-coenzyme A synthetase 2-like, mitochondrial - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
ACSS1 »  Acetyl-coenzyme A synthetase 2-like, mitochondrial   [ EC 6.2.1.1 ]
 
Protein also known as:  Acyl-CoA synthetase short-chain family member 1.
Gene name:  ACSS1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 25 4
GENE REF ISO

Function

 show evidences
Overview 
Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2).  
2
  • UniProtKB
GO molecular function 
Acetate-CoA ligase activitydefinition[GO:0003987]  
1
  • UniProtKB
AMP bindingdefinition[GO:0016208] silver  
1
  • InterPro 2 GO
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
2
  • UniProtKB
GO biological process 
Acetate biosynthetic processdefinition[GO:0019413] silver  
1
  • Ortholog Compara
Acetyl-CoA biosynthetic processdefinition[GO:0006085]  
1
  • UniProtKB
Acetyl-CoA biosynthetic process from acetatedefinition[GO:0019427] silver  
1
  • InterPro 2 GO
Propionate biosynthetic processdefinition[GO:0019542] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.2.1.1: ATP + acetate + CoA AMP + diphosphate + acetyl-CoA.  
1
  • UniProtKB
It is regulated in the following manner
Inhibited by acetylation at Lys-642 and activated by deacetylation.  
2
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Glycolysis / Gluconeogenesis  hsa00010+84532  
Metabolic pathways  hsa01100+84532  
Propanoate metabolism  hsa00640+84532  
Pyruvate metabolism  hsa00620+84532  
According to Reactome, this protein belongs to the following pathway:
Ethanol oxidation  REACT_34  
 

Keywords

Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 84532
PRO: PR:Q9NUB1