ACSS1 - Acetyl-coenzyme A synthetase 2-like, mitochondrial - human protein (Function)
 
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ACSS1 »  Acetyl-coenzyme A synthetase 2-like, mitochondrial   [ EC 6.2.1.1 ]
 
Protein also known as:  Acyl-CoA synthetase short-chain family member 1.
Gene name:  ACSS1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 23 4
GENE REF ISO

Function

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Overview 
Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2).  
1
  • CuratedUniProtKB
GO molecular function 
Acetate-CoA ligase activitydefinition[GO:0003987]  
1
  • IDAUniProtKB
AMP bindingdefinition[GO:0016208] silver  
  • IEAInterPro 2 GO
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
GO biological process 
Acetate biosynthetic processdefinition[GO:0019413] silver  
  • IEAOrtholog Compara
Acetyl-CoA biosynthetic processdefinition[GO:0006085]  
1
  • IDAUniProtKB
Acetyl-CoA biosynthetic process from acetatedefinition[GO:0019427] silver  
  • IEAInterPro 2 GO
Propionate biosynthetic processdefinition[GO:0019542] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.2.1.1: ATP + acetate + CoA AMP + diphosphate + acetyl-CoA.  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by acetylation at Lys-642 and activated by deacetylation.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Glycolysis / Gluconeogenesis  hsa00010+84532  
Metabolic pathways  hsa01100+84532  
Propanoate metabolism  hsa00640+84532  
Pyruvate metabolism  hsa00620+84532  
According to Reactome, this protein belongs to the following pathway:
Ethanol oxidation  REACT_34  
 

Keywords

Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 84532
PRO: PR:Q9NUB1