AGPAT5 - 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon - human protein (Function)
 
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References

 
AGPAT5 »  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon   [ EC 2.3.1.51 ]
 
Protein also known as:  1-acylglycerol-3-phosphate O-acyltransferase 5 (1-AGPAT 5).
Gene name:  AGPAT5
Entry whose protein(s) existence is based on evidence at protein level
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1 16 1
GENE REF ISO

Function

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Overview 
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor. Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA. Activity toward lysophosphatidylglycerol not detectable.  
1
  • CuratedUniProtKB
GO molecular function 
1-acylglycerol-3-phosphate O-acyltransferase activitydefinition[GO:0003841]  
1
  • NASUniProtKB
GO biological process 
CDP-diacylglycerol biosynthetic processdefinition[GO:0016024]  
  • IEAUniPathway
Phospholipid biosynthetic processdefinition[GO:0008654]  
1
  • NASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.51: Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate CoA + 1,2-diacyl-sn-glycerol 3-phosphate.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to Reactome, this protein belongs to the following pathways:
Synthesis of PA  REACT_120906  
Triglyceride Biosynthesis  REACT_1190  
 
More information is available from:
 

Biophysicochemical properties

Kinetic parameters
KM 16.30 uM for C18:1-CoA
KM 5.52 uM for LPA sn-1 C18:1
Vmax 1.22 nmol/min/mg enzyme toward C18:1-CoA
Vmax 2.42 nmol/min/mg enzyme toward LPA sn-1 C18:1

Keywords

Biological process 
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Phospholipid biosynthesis  definition   [KW-0594]
Phospholipid metabolism  definition   [KW-1208]
Molecular function 
Acyltransferase  definition   [KW-0012]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: AGPAT5
GenomeRNAi: 55326
PRO: PR:Q9NUQ2