POLR3B - DNA-directed RNA polymerase III subunit RPC2 - human protein (Function)
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POLR3B »  DNA-directed RNA polymerase III subunit RPC2   [ EC ]  (RNA polymerase III subunit C2)
Protein also known as:  DNA-directed RNA polymerase III 127.6 kDa polypeptide.
Gene name:  POLR3B
Entry whose protein(s) existence is based on evidence at protein level
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DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.  
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677] silver  
  • IEAInterPro 2 GO
DNA-directed RNA polymerase activitydefinition[GO:0003899]  
  • IEAEC 2 GO
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Ribonucleoside bindingdefinition[GO:0032549] silver  
  • IEAInterPro 2 GO
GO biological process 
Defense response to virusdefinition[GO:0051607]  
  • IEAUniProtKB KW
Positive regulation of innate immune responsedefinition[GO:0045089]  
  • IMPUniProtKB
Positive regulation of interferon-beta productiondefinition[GO:0032728]  
  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC Nucleoside triphosphate + RNA(n) diphosphate + RNA(n+1).  
  • CuratedUniProtKB
According to KEGG, this protein belongs to the following pathways:
Cytosolic DNA-sensing pathway  hsa04623+55703  
Metabolic pathways  hsa01100+55703  
Purine metabolism  hsa00230+55703  
Pyrimidine metabolism  hsa00240+55703  
RNA polymerase  hsa03020+55703  
According to Reactome, this protein belongs to the following pathways:
RNA Polymerase III Abortive And Retractive Initiation  REACT_22339  
RNA Polymerase III Chain Elongation  REACT_756  
RNA Polymerase III Transcription Initiation From Type 1 Promoter  REACT_347  
RNA Polymerase III Transcription Initiation From Type 2 Promoter  REACT_1036  
RNA Polymerase III Transcription Initiation From Type 3 Promoter  REACT_571  
RNA Polymerase III Transcription Termination  REACT_63  


Biological process 
Antiviral defense  definition   [KW-0051]
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Transcription  definition   [KW-0804]
Molecular function 
Nucleotidyltransferase  definition   [KW-0548]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GenomeRNAi: 55703