FANCL - E3 ubiquitin-protein ligase FANCL - human protein (Function)
 
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Protein
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References

 
FANCL »  E3 ubiquitin-protein ligase FANCL   [ EC 6.3.2.- ]
 
Protein also known as:  Fanconi anemia-associated polypeptide of 43 kDa (FAAP43).
Gene name:  FANCL
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 35 2
GENE REF ISO

Function

 show evidences
Overview 
Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.  
5
  • CuratedUniProtKB
GO molecular function 
Ligase activitydefinition[GO:0016874]  
  • IEAUniProtKB KW
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
3
  • IPIUniProtKB
Ubiquitin-protein transferase activitydefinition[GO:0004842]  
2
  • IDAUniProtKB
  • ISSOrtholog Curator
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • IMPUniProtKB
DNA repairdefinition[GO:0006281]  
1
  • IMPUniProtKB
Gamete generationdefinition[GO:0007276] silver  
  • IEAOrtholog Compara
Protein monoubiquitinationdefinition[GO:0006513]  
1
  • IDAUniProtKB
Regulation of cell proliferationdefinition[GO:0042127] silver  
  • IEAOrtholog Compara
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Fanconi anemia pathway  hsa03460+55120  
Ubiquitin mediated proteolysis  hsa04120+55120  
According to Reactome, this protein belongs to the following pathway:
Fanconi Anemia pathway  REACT_18410  
Caution 
Although PubMed12724401 reports that it contains a PHD-type zinc finger, it contains a RING-type zinc finger. Moreover, PHD-type zinc fingers do not have any ubiquitin ligase activity.  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FANCL
GenomeRNAi: 55120
PRO: PR:Q9NW38