BABAM1 - BRISC and BRCA1-A complex member 1 - human protein (Function)
 
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BABAM1 »  BRISC and BRCA1-A complex member 1
 
Protein also known as:  Mediator of RAP80 interactions and targeting subunit of 40 kDa.
Gene name:  BABAM1
Family name: BABAM1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 31 3
GENE REF ISO

Function

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Overview 
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component.  
3
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Chromatin modificationdefinition[GO:0016568]  
  • IEAUniProtKB KW
Double-strand break repairdefinition[GO:0006302]  
3
  • IMPUniProtKB
G2 DNA damage checkpointdefinition[GO:0031572]  
3
  • IMPUniProtKB
Positive regulation of DNA repairdefinition[GO:0045739]  
3
  • IMPUniProtKB
Protein K63-linked deubiquitinationdefinition[GO:0070536]  
1
  • IMPUniProtKB
Response to ionizing radiationdefinition[GO:0010212]  
2
  • IMPUniProtKB
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Molecular function 
Chromatin regulator  definition   [KW-0156]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: C19orf62
GenomeRNAi: 29086
PRO: PR:Q9NWV8