NHP2 - H/ACA ribonucleoprotein complex subunit 2 - human protein (Function)
 
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Protein
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References

 
NHP2 »  H/ACA ribonucleoprotein complex subunit 2
 
Protein also known as:  Nucleolar protein family A member 2.
Gene name:  NHP2
Family name: Ribosomal protein L7Ae
Entry whose protein(s) existence is based on evidence at protein level
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1 21 1
GENE REF ISO

Function

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Overview 
Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.  
1
  • CuratedUniProtKB
GO molecular function 
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
snoRNA bindingdefinition[GO:0030515]  
  • ISSOrtholog Curator
GO biological process 
rRNA pseudouridine synthesisdefinition[GO:0031118]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathway:
Ribosome biogenesis in eukaryotes  hsa03008+55651  
According to Reactome, this protein belongs to the following pathway:
Telomere Extension By Telomerase  REACT_7974  
 

Keywords

Biological process 
Ribosome biogenesis  definition   [KW-0690]
rRNA processing  definition   [KW-0698]
Molecular function 
Ribonucleoprotein  definition   [KW-0687]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: NOLA2
GenomeRNAi: 55651
PRO: PR:Q9NX24