ADPRHL2 - Poly(ADP-ribose) glycohydrolase ARH3 - human protein (Function)
 
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ADPRHL2 »  Poly(ADP-ribose) glycohydrolase ARH3   [ EC 3.2.1.143 ]
 
Protein also known as:  [Protein ADP-ribosylarginine] hydrolase-like protein 2.
Gene name:  ADPRHL2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP-ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria.  
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  • CuratedUniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Poly(ADP-ribose) glycohydrolase activitydefinition[GO:0004649]  
  • IEAEC 2 GO
GO biological process 
Metabolic processdefinition[GO:0008152]  
  • IEAEC 2 GO
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.2.1.143: Hydrolyzes poly(ADP-D-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-D-ribose.  
1
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 magnesium ions per subunit.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Activity is enhanced by magnesium.  
1
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ADPRHL2
GenomeRNAi: 54936
PRO: PR:Q9NX46