SCN3A - Sodium channel protein type 3 subunit alpha - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
SCN3A »  Sodium channel protein type 3 subunit alpha
 
Protein also known as:  Voltage-gated sodium channel subunit alpha Nav1.3.
Gene name:  SCN3A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 42 4
GENE REF ISO

Function

 show evidences
Overview 
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.  
  • CuratedUniProtKB
GO molecular function 
Voltage-gated sodium channel activitydefinition[GO:0005248]  
1
  • NASUniProtKB
GO biological process 
Membrane depolarization during action potentialdefinition[GO:0086010] silver  
  • IBARefGenome
Neuronal action potentialdefinition[GO:0019228] silver  
  • IBARefGenome
Regulation of ion transmembrane transportdefinition[GO:0034765]  
  • IEAUniProtKB KW
Sodium ion transmembrane transportdefinition[GO:0035725]  
1
  • NASGOC
  • IEAUniProtKB KW
  • IEAInterPro 2 GO
Sodium ion transportdefinition[GO:0006814]  
1
  • NASUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Interaction between L1 and Ankyrins  REACT_22266  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Sodium transport  definition   [KW-0739]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Sodium channel  definition   [KW-0894]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: SCN3A
GenomeRNAi: 6328
PRO: PR:Q9NY46
Chemistry
GuidetoPHARMACOLOGY: 580